1642300-78-4
1642300-78-4
Chemical Structure
Eltanexor Z-isomer
Synonym(s): KPT-8602 (Z-isomer)
- CAS No.: 1642300-78-4
- Formula:C17H10F6N6O
- Molecular Weight:428.29
IUPAC Name: (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide
InChIKey: JFBAVWVBLRIWHM-MLPAPPSSSA-N
SMILES: O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Eltanexor Z-isomer | 95.98% | Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. | ||||||||||||||||||||
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Eltanexor Z-isomer (Standard) | ≥98% | Eltanexor Z-isomer (Standard) is the analytical standard of Eltanexor Z-isomer (HY-100423A). This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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References
- Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25. [Content Brief]
- Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21. [Content Brief]
- Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24. [Content Brief]
