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LFS-1107

LFS-1107 is a reversible CRM1 inhibitor (K_d: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 1799330-91-8
Formula: C₁₂H₁₁N₅OS₂
Molecular Weight:305.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LFS-1107 Chemical Structure

CAS No.: 1799330-91-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

LFS-1107 is a reversible CRM1 inhibitor (K_d: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research^[1].

IC₅₀ & Target

COX-2

All COX Isoforms :

In Vitro

LFS-1107 (4-9 μM, 72 h) can selectively eliminate ENKTL cells while sparing normal human PBMC with good safety profile in PBMC cell lines^[1].
LFS-1107 (0.15-500 μM, 24 h) barely exhibits any effects in human platelets^[1].
LFS-1107 (50-200 nM, 3 h) can lead to nuclear accumulation IκBα in 293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SNK6, HANK-1
Concentration:

0-800 nM
Incubation Time:

72 h
Result:

Achieved IC₅₀ value of 26 nM in SNK6 cell line and 36 nM in HANK-1 cell line.

Western Blot Analysis^[1]

Cell Line:

SNK6
Concentration:

62.5 nM, 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time:

3 h
Result:

Suppressed the expression of CRM1 in a dose-dependent manner.
Downregulated the expression of proinflammatory and proliferative proteins p65, COX-2, c-Myc, and Survivin in a dose dependent manner.

Immunofluorescence^[1]

Cell Line:

293T cells
Concentration:

50 nM, 100 nM, 200 nM
Incubation Time:

3 h
Result:

Could lead to nuclear accumulation of IκBα in a dose dependent manner.

In Vivo

LFS-1107 (10 mg/kg, Intraperitoneal injection,once a week) can ameliorate the symptoms of ENKTL in SNK6 cell xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SNK6 cell xenograft mouse model^[1]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection (i.p.), once a week
Result:

Extended mouse survival and Eliminated tumor cells.

Chemical Information

CAS No. 1799330-91-8
Molecular Weight 305.38
Formula C₁₂H₁₁N₅OS₂
SMILES

O=S(C1=NN=NN1C2=CC=CC=C2)/C=C/CCN=C=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He Liu, et al. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma eLife 12:e80625.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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