Selinexor (Synonyms: KPT-330)

Name: Selinexor
Brand: MedChemExpress
SKU: HY-17536
Rating: 5.0 (9 reviews)

Cat. No.: HY-17536 Purity: 99.83%: Data Sheet
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Selinexor (KPT-330) is an analog of KPT-185 (HY-15611). Selinexor is an orally active, selective CRM1 inhibitor that inhibits tumor growth by inducing PANoptosis.

For research use only. We do not sell to patients.

CAS No. : 1393477-72-9

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Selinexor:

Selinexor-d₅ Get quote
Selinexor (Standard) Get quote

9 Publications Citing Use of MCE Selinexor

IHC

Flow Cytometry

Apoptosis Analysis

: Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948. [Abstract]; From the above animal model, the tumors were isolated and examined by immunohistochemistry and quantified by ImageJ to detect cleaved caspase3 protein expression in CTR-KD and HCG11-KD tumors treated with Selinexor (10 mg/kg, twice per week) or PBS.

: Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948. [Abstract]; Western blotting of PARP, cleaved PARP and cleaved caspase 3 in CTR-KD and XPO1-KD ARD cells treated with Selinexor (0.25 μM, 12 h).

: Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948. [Abstract]; Apoptosis rates of CTR-KD and XPO1-KD ARD cells treated with Selinexor (0.25 μM, 48 h).

: Selinexor purchased from MedChemExpress. Usage Cited in: Leukemia. 2023 Jun;37(6):1336-1348. [Abstract]; Percent apoptotic cells following KO of mtNPM1 and treatment with Selinexor (KPT-330, 30-1000 nM) at the indicated concentrations for 48 hours.

: Selinexor purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2023 Jul 3;19(11):3412-3427.; HCCLM3 cells were treated with or without TNF-α and Selinexor (1 mM, 72 hours) followed by STAT3 co-immunoprecipitation assay.

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Description

Selinexor (KPT-330) is an analog of KPT-185 (HY-15611). Selinexor is an orally active, selective CRM1 inhibitor that inhibits tumor growth by inducing PANoptosis^[1]^[2]^[3].

IC₅₀ & Target

CRM1

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	0.73 μM Compound: KPT-330	Cytotoxicity against HEK293T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Cytotoxicity against HEK293T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 38105606]
HPBALL	IC₅₀	34 nM Compound: KPT-330	Antiproliferative activity against human HPBALL cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay Antiproliferative activity against human HPBALL cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay	[PMID: 38105606]
HeLa	IC₅₀	0.43 μM Compound: KPT-330	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 38105606]
Jurkat	EC₅₀	17 nM Compound: 1; KPT-330	Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay	[PMID: 39005064]
Jurkat	IC₅₀	34 nM Compound: KPT-330	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay	[PMID: 38105606]
KOPTK1	IC₅₀	34 nM Compound: KPT-330	Antiproliferative activity against human KOPT-K1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay Antiproliferative activity against human KOPT-K1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay	[PMID: 38105606]
MOLT-4	IC₅₀	34 nM Compound: KPT-330	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay	[PMID: 38105606]
NSCLC	IC₅₀	25 nM Compound: 2; KPT-330	Antitumor activity against human NSCLC cells Antitumor activity against human NSCLC cells	[PMID: 34669417]

In Vitro

As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC₅₀ values of 34-203 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Selinexor (KPT-330) dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells^[1].
In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

443.31

Formula

C₁₇H₁₁F₆N₇O

CAS No.

1393477-72-9

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NNC1=NC=CN=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (225.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2558 mL	11.2788 mL	22.5576 mL
5 mM	0.4512 mL	2.2558 mL	4.5115 mL
10 mM	0.2256 mL	1.1279 mL	2.2558 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.69 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (4.69 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (251 KB) HNMR (276 KB) RP-HPLC (208 KB) LCMS (264 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161(1):117-27. [Content Brief]

[2]. Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28(1):155-65. [Content Brief]

[3]. Camilli S, et al. Nuclear Export Inhibitors Selinexor (KPT-330) and Eltanexor (KPT-8602) Provide a Novel Therapy to Reduce Tumor Growth by Induction of PANoptosis. Cell Biochem Biophys. 2023 Sep;81(3):421-426. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2558 mL	11.2788 mL	22.5576 mL	56.3939 mL
	5 mM	0.4512 mL	2.2558 mL	4.5115 mL	11.2788 mL
	10 mM	0.2256 mL	1.1279 mL	2.2558 mL	5.6394 mL
	15 mM	0.1504 mL	0.7519 mL	1.5038 mL	3.7596 mL
	20 mM	0.1128 mL	0.5639 mL	1.1279 mL	2.8197 mL
	25 mM	0.0902 mL	0.4512 mL	0.9023 mL	2.2558 mL
	30 mM	0.0752 mL	0.3760 mL	0.7519 mL	1.8798 mL
	40 mM	0.0564 mL	0.2820 mL	0.5639 mL	1.4098 mL
	50 mM	0.0451 mL	0.2256 mL	0.4512 mL	1.1279 mL
	60 mM	0.0376 mL	0.1880 mL	0.3760 mL	0.9399 mL
	80 mM	0.0282 mL	0.1410 mL	0.2820 mL	0.7049 mL
	100 mM	0.0226 mL	0.1128 mL	0.2256 mL	0.5639 mL

Selinexor Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selinexor1393477-72-9KPT-330KPT330KPT 330CRM1PANoptosisChromosomal Maintenance 1Exportin 1XPO1Inhibitorinhibitorinhibit

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Selinexor (Synonyms: KPT-330)

Customer Review

Other Forms of Selinexor:

Selinexor Related Antibodies

9 Publications Citing Use of MCE Selinexor

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•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

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Complete Stock Solution Preparation Table

Selinexor Related Classifications

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