2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. CRM1
  5. CRM1 Inhibitor

CRM1 Inhibitor

CRM1 Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-17536
    Selinexor
    		Inhibitor 99.85%
    Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective CRM1 inhibitor.
  • HY-15970
    Verdinexor
    		Inhibitor 99.91%
    Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus replication in vitro and in vivo.
  • HY-100423A
    Eltanexor Z-isomer
    		Inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.
  • HY-157412
    CRM1-IN-3
    		Inhibitor
    CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor.
  • HY-117996
    KPT-251
    		Inhibitor 98.54%
    KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity.
  • HY-155972A
    CRM1-IN-2
    		Inhibitor
    CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis.
  • HY-155972
    CRM1-IN-1
    		Inhibitor
    CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells.
  • HY-114597
    PKF050-638
    		Inhibitor
    PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction.
  • HY-N6795
    Leptomycin A
    		Inhibitor ≥99.0%
    Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B.