1. Membrane Transporter/Ion Channel
  2. CRM1
  3. CBS9106

CBS9106 (Synonyms: SL-801)

Cat. No.: HY-108716
Handling Instructions

CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities.

For research use only. We do not sell to patients.

CBS9106 Chemical Structure

CBS9106 Chemical Structure

CAS No. : 1076235-04-5

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Description

CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities[1].

IC50 & Target

CRM1[1]

In Vitro

CBS9106 (0.01-10 μM; 72 hours) sensitizes cells to radiation and to suppress the growth of a variety of cancer cell lines. The estimated IC50 values range from 22.3 or 35.6 nM in multiple myeloma (MM).1S or RPMI-8226 cells and from 3 to 278 nM in 60 other human cancer cell lines[1].
CBS9106 (1-400 nM; 24 hours) decreases CRM1 protein expression levels in a dose-dependent manner[1].

Cell Viability Assay[1]

Cell Line: MM.1S cells, RPMI-8226 cells
Concentration: 0.01, 0.1, 10 μM
Incubation Time: 72 hours
Result: Suppressed the growth of a variety of cancer cell lines and the estimated IC50 values ranged from 22.3 or 35.6 nM in MM.1S or RPMI-8226 cells.

Western Blot Analysis[1]

Cell Line: MM.1S cells
Concentration: 1, 3, 6, 12, 25, 50, 100, 200, 400 nM
Incubation Time: 24 hours
Result: The level of CRM1 protein expression markedly reduced in a dose-dependent manner.
In Vivo

CBS9106 (31.25-62.5 mg/kg for 5 times weekly, 125 mg/kg for 3 times weekly; p.o.; 2 weeks) significantly suppresses tumor growth at dose levels of 62.5 or 125 mg/kg in mice bearing human MM xenograft models[1].

Animal Model: SCID mice with RPMI-8226 cells[1]
Dosage: 31.25, 62.5, 125 mg/kg
Administration: Oal administration; 5 times weekly (31.25 and 62.5 mg/kg), 3 times weekly (125 mg/kg); 2 weeks
Result: Showed statistically significant tumor growth inhibition at dose levels of 62.5 mg/kg or 125 mg/kg.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

419.83

Formula

C₁₈H₂₁ClF₃N₃O₃

CAS No.

1076235-04-5

SMILES

O=C(C(COCCC(C)(C)C)=C1C)N(NC2=NC(Cl)=C(C(F)(F)F)C=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere

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CBS9106
Cat. No.:
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CBS9106

Cat. No.: HY-108716