Histamine Receptor Activator

Histamine-α,α,β,β-d₄ (dihydrochloride) is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

6-O-Senesioyl plenolin is a sesquiterpene lactone found in Centipeda minima with antiallergic activity. 6-O-Senesioyl plenolin inhibits histamine release from mast cells (IC₅₀ = 18 μM) and suppresses pigment exudation in passive cutaneous anaphylaxis tests. 6-O-Senesioyl plenolin can be used in research related to allergy.

Histamine/OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MFDCH016 is a potent HDAC1/6 (IC₅₀ = 38/59 nM) and CDK4/6 (IC₅₀ = 680/720 nM) inhibitor. MFDCH016 induces apoptosis and cell cycle arrest in G2/M and G0/G1 phases in MCF-7 cells. MFDCH016 can modulate the HDAC-p21-CDK signaling pathway, increasing the levels of acetylated H3 and p21. MFDCH016 can be used for the study of breast cancer.

AHR-1911 (10-Undecen-1-yl-Thiopseudourea Iodide;Isothiuronium) is a thiourea-based anti-inflammatory and anti-tumor agent that has an improving effect on burned skin. AHR-1911 produces histamine-like effects when injected intradermally and may reduce arterial pressure in anesthetized dogs. AHR-1911 inhibits tumor growth and reduces microsomal and C-polysome protein synthesis.