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Cat. No.: HY-N19243

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6-O-Senesioyl plenolin

6-O-Senesioyl plenolin is a sesquiterpene lactone found in Centipeda minima with antiallergic activity. 6-O-Senesioyl plenolin inhibits histamine release from mast cells (IC₅₀ = 18 μM) and suppresses pigment exudation in passive cutaneous anaphylaxis tests. 6-O-Senesioyl plenolin can be used in research related to allergy.

For research use only. We do not sell to patients.

CAS No.: 90042-11-8
Formula: C₂₀H₂₆O₅
Molecular Weight:346.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

6-O-Senesioyl plenolin Chemical Structure

CAS No.: 90042-11-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Histamine Receptor Isoforms :

In Vitro

6-O-Senesioyl plenolin (compound 2) inhibits Concanavalin A (HY-P2149)-induced histamine release from rat peritoneal mast cells with an IC₅₀ of 18 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 90042-11-8
Molecular Weight 346.42
Formula C₂₀H₂₆O₅
SMILES

O(C(C=C(C)C)=O)[C@H]1[C@]2([C@@](C[C@@H](C)[C@]3([C@@]1(C)C(=O)C=C3)[H])(OC(=O)[C@H]2C)[H])[H]
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source

CENTIPEDA MINIMA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu JB, et al. Biologically active constituents of Centipeda minima: isolation of a new plenolin ester and the antiallergy activity of sesquiterpene lactones. Chem Pharm Bull (Tokyo). 1985 Sep;33(9):4091-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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