1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Membrane Transporter/Ion Channel
  2. Histamine Receptor
    Potassium Channel
  3. Astemizole

Astemizole (Synonyms: R 43512)

Cat. No.: HY-12532 Purity: >98.0%
Handling Instructions

Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects.

For research use only. We do not sell to patients.

Astemizole Chemical Structure

Astemizole Chemical Structure

CAS No. : 68844-77-9

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
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Description

Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects[1][2].

Molecular Weight

458.57

Formula

C₂₈H₃₁FN₄O

CAS No.

68844-77-9

SMILES

COC1=CC=C(CCN2CCC(NC3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Astemizole
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