1. GPCR/G Protein
    Immunology/Inflammation
    Membrane Transporter/Ion Channel
  2. Histamine Receptor
    Potassium Channel
  3. Astemizole

Astemizole (Synonyms: R 43512)

Cat. No.: HY-12532
Handling Instructions

Astemizole, a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has anticholinergic and antipruritic effects.

For research use only. We do not sell to patients.

Astemizole Chemical Structure

Astemizole Chemical Structure

CAS No. : 68844-77-9

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Description

Astemizole, a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has anticholinergic and antipruritic effects[1][2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

458.57

Formula

C₂₈H₃₁FN₄O

CAS No.

68844-77-9

SMILES

COC1=CC=C(CCN2CCC(NC3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)C=C1

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Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Astemizole
Cat. No.:
HY-12532
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Astemizole

Cat. No.: HY-12532