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Cat. No.: HY-N11732

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O-Demethylrotenone

O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD₅₀ of O-Demethylrotenone in Mus musculus is 8.0 mg/kg.

For research use only. We do not sell to patients.

CAS No.: 36375-21-0
Formula: C₂₂H₂₀O₆
Molecular Weight:380.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

O-Demethylrotenone Chemical Structure

CAS No.: 36375-21-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

O-Demethylrotenone (1 g rotenone, equimolar boron tribromide, 12 mL dichloromethane; 2 min at -10 °C) is synthesized from rotenone via demethylation with boron tribromide, exhibits characteristic spectral and physical properties, and can be converted back to rotenone via methylation^[1].
O-Demethylrotenone (1 g rotenone in 600 mL methanol; 2 hr ultraviolet irradiation with oxygen bubbling) is a neutral product of rotenone photodecomposition in oxygenated methanol solution under ultraviolet irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

O-Demethylrotenone (8.0 mg/kg; i.p.; single dose) has a 24-hour intraperitoneal LD₅₀ of 8.0 mg/kg in adult male white mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

white mice (adult male)^[1]
Dosage:

8.0 mg/kg
Administration:

i.p.; single dose
Result:

Determined a 24-hour intraperitoneal LD₅₀ of 8.0 mg/kg.

Chemical Information

CAS No. 36375-21-0
Molecular Weight 380.39
Formula C₂₂H₂₀O₆
SMILES

O=C1[C@@]2([H])C3=CC(OC)=C(O)C=C3OC[C@@]2([H])OC4=C(C[C@@H](O5)C(C)=C)C5=CC=C41
Structure Classification
- Ketones, Aldehydes, Acids
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheng H M, et al. Rotenone photodecomposition[J]. Journal of agricultural and food chemistry, 1972, 20(4): 850-856.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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