O-Demethylrotenone 

O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD₅₀ of O-Demethylrotenone in Mus musculus is 8.0 mg/kg^[1].

O-Demethylrotenone (1 g rotenone, equimolar boron tribromide, 12 mL dichloromethane; 2 min at -10 °C) is synthesized from rotenone via demethylation with boron tribromide, exhibits characteristic spectral and physical properties, and can be converted back to rotenone via methylation^[1].
O-Demethylrotenone (1 g rotenone in 600 mL methanol; 2 hr ultraviolet irradiation with oxygen bubbling) is a neutral product of rotenone photodecomposition in oxygenated methanol solution under ultraviolet irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

O-Demethylrotenone (8.0 mg/kg; i.p.; single dose) has a 24-hour intraperitoneal LD₅₀ of 8.0 mg/kg in adult male white mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

380.39

C₂₂H₂₀O₆

36375-21-0

O=C1[C@@]2([H])C3=CC(OC)=C(O)C=C3OC[C@@]2([H])OC4=C(C[C@@H](O5)C(C)=C)C5=CC=C41

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheng H M, et al. Rotenone photodecomposition[J]. Journal of agricultural and food chemistry, 1972, 20(4): 850-856.