484-33-3
Chemical Structure
Pongamol
Synonym(s): Lanceolatin C
- CAS No.: 484-33-3
- Formula:C18H14O4
- Molecular Weight:294.30
IUPAC Name: 1-(4-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione
InChIKey: XTLSKKJNOIMMBK-UHFFFAOYSA-N
SMILES: O=C(CC(C1=CC=CC=C1)=O)C2=CC=C3OC=CC3=C2OC
Biological Activity: Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia[1][2][3][4][5][6][7].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Pongamol | 99.81% | Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia. | ||||||||||||||||||||
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Furobufen | 99.74% | Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue. | ||||||||||||||||||||
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Dalosirvat | 98.22% | Dalosirvat (SM-04554) is a potent Wnt activator with an EC50s of 28-29 nM. Dalosirvat can be used in the study of cancer. | ||||||||||||||||||||
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Avobenzone | 98.0% | Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist. | ||||||||||||||||||||
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Menbutone | 98.38% | Menbutone (Genabilic acid), an oxobutyric acid derivative, is a choleretic. Menbutone can be used to treat digestive upsets (loss of appetite, indigestion, toxemia, or hepatic and pancreatic insufficiencies) in a variety of animal species, including different farm animals (cattle, sheep, goats, pigs), as well as in dogs. | ||||||||||||||||||||
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α,β-Dihydro-4,6-dihydroxy-2-methoxy-3-methylchalcone | α,β-Dihydro-4,6-dihydroxy-2-methoxy-3-methylchalcone (compound 7) is a nature product that could be isolated from dragons blood of Daemonorops draco. | |||||||||||||||||||||
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Ovalitenone | Ovalitenone is a flavonoid found in the plant Millettia peguensis and acts as a CYP1A1/CYP1B1 inhibitor with IC50 values of 0.28 and 0.6 μM, respectively. Ovalitenone significantly decreases the levels of N-cadherin, snail, and slug while increasing E-cadherin, thereby inhibiting the EMT pathway. Ovalitenone also inhibits the regulatory signaling pathways of focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42). Ovalitenone inhibits the proliferation, migration, invasion, epithelial-mesenchymal transition, and cancer stem cell-like phenotype of lung cancer cells. Ovalitenone can be used in lung cancer-related research. | |||||||||||||||||||||
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β-Hydroxy-2',4',5'-trimethoxychalcone | β-Hydroxy-2',4',5'-trimethoxychalcone is a natural chalcone. | |||||||||||||||||||||
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Dibenzoylmethane | 98.0% | Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2. | ||||||||||||||||||||
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ST026567 | ST026567 is a potent mast cell activator. ST026567 induces the secretion of PGD2, LTC4 from cells. ST026567 exhibits degranulation potency. | |||||||||||||||||||||
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WAY-301398 | 95.0% | WAY-301398 is an active molecule for the study of amyloid diseases and synucleinopathies. | ||||||||||||||||||||
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References
- [1]. Hu K, et al. Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway. J Agric Food Chem. Published online June 6, 2024. [Content Brief]
- [2]. Tamrakar AK, et al. Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells. Mol Cell Endocrinol. 2011;339(1-2):98-104. [Content Brief]
- [3]. Wu S, et al. Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans. Mol Neurobiol. 2024;61(10):8219-8233. [Content Brief]
- [4]. Putri HE, et al. Pongamol Inhibits Epithelial to Mesenchymal Transition Through Suppression of FAK/Akt-mTOR Signaling. Anticancer Res. 2021;41(12):6147-6154. [Content Brief]
- [5]. Tamrakar AK, et al. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. J Ethnopharmacol. 2008;118(3):435-439. [Content Brief]
- [6]. Ranga Rao R, et al. New furanoflavanoids, intestinal alpha-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.). Bioorg Med Chem. 2009;17(14):5170-5175. [Content Brief]
- [7]. Jahan S, et al. Health promoting benefits of pongamol: An overview. Biomed Pharmacother. 2021 Oct;142:112109. [Content Brief]
