1. NF-κB
  2. Keap1-Nrf2
  3. Dibenzoylmethane

Dibenzoylmethane 

Cat. No.: HY-W009731
Handling Instructions

Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2.

For research use only. We do not sell to patients.

Dibenzoylmethane Chemical Structure

Dibenzoylmethane Chemical Structure

CAS No. : 120-46-7

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Based on 1 publication(s) in Google Scholar

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Description

Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].

In Vitro

Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h[1].
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice[1].
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

224.26

Formula

C₁₅H₁₂O₂

CAS No.

120-46-7

SMILES

O=C(C1=CC=CC=C1)CC(C2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

DibenzoylmethaneKeap1-Nrf2curcuminnucleartranslocationHO-1HepG2phosphorylatedErk1/2p38MAPKJNKAMPKAktInhibitorinhibitorinhibit

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