Avobenzone 

Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist^[1][2].

Avobenzone (EC₅₀=14.1 μM) significantly promots adipogenesis in hBM-MSCs as its positive control obesogenic chemicals. Avobenzone (10 μM) significantly up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs^[2].
Avobenzone (1-50 μM; 48 hours) inhibits proliferative activities of human trophoblast cells^[3].
Avobenzone (1-50 μM; 48 hours) induces apoptosis in HTR8/SVneo cells^[3].
Avobenzone only shows weak ERa agonism and weak AR antagonism^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

310.39

Solid

C₂₀H₂₂O₃

70356-09-1

O=C(C1=CC=C(C(C)(C)C)C=C1)CC(C2=CC=C(OC)C=C2)=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Kojić M, et al. A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations. Phys Chem Chem Phys. 2016;18(32):22168-22178.  [Content Brief]

  [2]. Ahn S, An S, et al. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93(7):1903-1915.  [Content Brief]

  [3]. Yang C, et al. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50-57.  [Content Brief]

  [4]. Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83(2):264-272.  [Content Brief]