Avobenzone-13C,d3
Based on 1 Customer Validation
Avobenzone-13C,d3 is the 13C- and deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
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- Pureté : 99.9%
- CAS No.: 2933758-47-3
- Formule: C1913CH19D3O3
- Masse moléculaire:314.40
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-W745880
UV-328-d12Stable Isotope -
HY-116807
Dihydrolipoic AcidAntioxidant -
HY-116807R
Dihydrolipoic Acid (Standard)Antioxidant -
HY-132429S
Potassium 1H-indol-3-yl sulfate-d5Stable Isotope -
HY-W040045
Callistephin chlorideROS/iNOS/TNF-α/COX-2 Inhibitor -
HY-111253
CYM-5478S1P2 Agonist -
HY-N3126
Orsellinic acidBenzoic Acid Derivative -
HY-N2413
Gomisin DLignan -
HY-N0915
MelittosideNatural Product -
HY-N3126R
Orsellinic acid (Standard)Standard Of Orsellinic Acid -
HY-W040045R
Callistephin chloride (Standard)Stanard of Callistephin chloride -
HY-N0915R
Melittoside (Standard)Natural Product
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[40].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2933758-47-3
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Unlabeled CAS 70356-09-1
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Appearance Solid
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Masse moléculaire 314.40
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Formule C1913CH19D3O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(C=C1)O[13C]([2H])([2H])[2H])CC(C2=CC=C(C=C2)C(C)(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
[2]. Kojić M, et al. A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations. Phys Chem Chem Phys. 2016;18(32):22168-22178. [Content Brief]
[3]. Ahn S, An S, et al. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93(7):1903-1915. [Content Brief]
[4]. Yang C, et al. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50-57. [Content Brief]
[5]. Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83(2):264-272. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avobenzone-13C,d3 Related Classifications
HY-B0316S Related Classifications
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