Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits

  • J Ethnopharmacol. 2008 Aug 13;118(3):435-9. doi: 10.1016/j.jep.2008.05.008.
Akhilesh K Tamrakar  1 ,  Prem P Yadav ,  Priti Tiwari ,  Rakesh Maurya ,  Arvind K Srivastava
Affiliations
  • 1. Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
PMID: 18572336 DOI: 10.1016/j.jep.2008.05.008
Abstract

Aim of the study: To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.

Material and methods: Streptozotocin-induced diabetic rats and hyperglycemic, hyperlipidemic and hyperinsulinemic db/db mice were used to investigate the antihyperglycemic activity of pongamol and karangin isolated from the fruits of Pongamia pinnata.

Results: In streptozotocin-induced diabetic rats, single dose treatment of pongamol and karanjin lowered the blood glucose level by 12.8% (p<0.05) and 11.7% (p<0.05) at 50mg /kg dose and 22.0% (p<0.01) and 20.7% (p<0.01) at 100mg/kg dose, respectively after 6h post-oral administration. The compounds also significantly lowered blood glucose level in db/db mice with percent activity of 35.7 (p<0.01) and 30.6 (p<0.01), respectively at 100mg/kg dose after consecutive treatment for 10 days. The compounds were observed to exert a significant inhibitory effect on enzyme protein tyrosine phosphatase-1B (EC 3.1.3.48).

Conclusion: The results showed that pongamol and karangin isolated from the fruits of Pongamia pinnata possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity.

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