84-02-6
Chemical Structure
Prochlorperazine dimaleate
- CAS No.: 84-02-6
- Formula:C28H32ClN3O8S
- Molecular Weight:606.09
IUPAC Name: 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine dimaleate
InChIKey: DSKIOWHQLUWFLG-SPIKMXEPSA-N
SMILES: O=C(O)/C=C\C(O)=O.CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O
Biological Activity: Prochlorperazine dimaleate is an orally active phenothiazine-type dopamine D2 receptor (D2R) antagonist. Prochlorperazine exhibits anti-cancer activity in vitro against various cancer cell lines. Prochlorperazine dimaleate exhibits IC50 values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively. Prochlorperazine dimaleate has antedesmosidic activity against dengue virus (DENV). Prochlorperazine dimaleate can be used for research on nausea, vomiting, migraine, and schizophrenia[1][2][3].
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Prochlorperazine dimaleate | 98.0% | Prochlorperazine dimaleate is an orally active phenothiazine-type dopamine D2 receptor (D2R) antagonist. Prochlorperazine exhibits anti-cancer activity in vitro against various cancer cell lines. Prochlorperazine dimaleate exhibits IC50 values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively. Prochlorperazine dimaleate has antedesmosidic activity against dengue virus (DENV). Prochlorperazine dimaleate can be used for research on nausea, vomiting, migraine, and schizophrenia. | ||||||||||||||||||||
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- [1]. Hoy SM, Scott LJ. Indomethacin/prochlorperazine/caffeine: a review of its use in the acute treatment of migraine and in the treatment of episodic tension-type headache. CNS Drugs. 2011 Apr;25(4):343-58. [Content Brief]
- [2]. Michał Otręba, et al. In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review. J Appl Toxicol. 2021 Jan;41(1):82-94. [Content Brief]
- [3]. Simanjuntak Y, et al. Repurposing of prochlorperazine for use against dengue virus infection. J Infect Dis. 2015 Feb 1;211(3):394-404. [Content Brief]
Keywords
