1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    Anti-infection
  2. Dopamine Receptor
    Sodium Channel
    SARS-CoV
  3. Fluphenazine dimaleate

Fluphenazine dimaleate 

Cat. No.: HY-119980A
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Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

For research use only. We do not sell to patients.

Fluphenazine dimaleate Chemical Structure

Fluphenazine dimaleate Chemical Structure

CAS No. : 3093-66-1

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Description

Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].

IC50 & Target

Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]

In Vivo

Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mature female Swiss-Webster mice[5]
Dosage: 1 mg/kg
Administration: IG, treated from day 6 to day 15 of gestation
Result: Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Animal Model: Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage: 0.125, 0.25, 0.5, and 1 mg/kg
Administration: IP, single dosage
Result: Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Molecular Weight

669.67

Formula

C30H34F3N3O9S

CAS No.
SMILES

OCCN(CC1)CCN1CCCN2C3=CC(C(F)(F)F)=CC=C3SC4=CC=CC=C42.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Fluphenazine dimaleate
Cat. No.:
HY-119980A
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