2. Neuronal Signaling GPCR/G Protein Membrane Transporter/Ion Channel Anti-infection
  3. Dopamine Receptor Sodium Channel SARS-CoV
  4. Fluphenazine hydrochloride

Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

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Fluphenazine hydrochloride Chemical Structure

Fluphenazine hydrochloride Chemical Structure

CAS No. : 1254-47-3

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Description

Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].

IC50 & Target

Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]
In Vivo

Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) hydrochloride causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes hydrochloride Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mature female Swiss-Webster mice[5]
Dosage: 1 mg/kg
Administration: IG, treated from day 6 to day 15 of gestation
Result: Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Animal Model: Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage: 0.125, 0.25, 0.5, and 1 mg/kg
Administration: IP, single dosage
Result: Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Molecular Weight

473.98

Formula

C22H27ClF3N3OS
CAS No.
SMILES

OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(C(F)(F)F)C=C24)CC1.[H]Cl
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fluphenazine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluphenazine1254-47-3Dopamine ReceptorSodium ChannelSARS-CoVNa channelsNa+ channelsSARS coronavirusneuronal voltage-gated sodium channelsoralschizophreniaphenothiazinegnawingclimbing behaviourpsychosisdiabetesSARS-CoV-2malformationsSwiss-Webster miceInhibitorinhibitorinhibit

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