Trifluoperazine dimaleate
Based on 10 publication(s) in Google Scholar
Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis.
For research use only. We do not sell to patients.
- CAS No.: 605-75-4
- Formula: C29H32F3N3O8S
- Molecular Weight:639.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Trifluoperazine dimaleate
More- J Transl Med. 2024 Aug 1;22(1):715. [Abstract]
- Free Radic Biol Med. 2025 Feb 1:227:64-79. [Abstract]
- CNS Neurosci Ther. 2023 Mar;29(3):831-841. [Abstract]
- Food Biosci. 2024 Feb, 57, 103513.
- Chem Biol Interact. 2024 Apr 1:392:110904. [Abstract]
- Mol Med Rep. 2021 May;23(5):319. [Abstract]
- Sci Rep. 2025 May 8;15(1):16053. [Abstract]
- BMC Med Genomics. 2024 Jan 2;17(1):12. [Abstract]
- Tohoku J Exp Med. 2022 Jul 22;257(4):315-326. [Abstract]
- bioRxiv. 2024 June 12.
All Dopamine Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Trifluoperazine dimaleate is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dimaleate has been an extensively studied drug molecule that has been used as a calmodulin inhibitor[3][4].
Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 605-75-4
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Molecular Weight 639.64
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Formula C29H32F3N3O8S
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SMILES
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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J Transl Med
Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway. [Abstract]2024 Aug 1;22(1):715. PMID: 39090667 -
Free Radic Biol Med
Zinc ions facilitate metabolic bioenergetic recovery post spinal cord injury by activating microglial mitophagy through the STAT3-FOXO3a-SOD2 pathway. [Abstract]2025 Feb 1:227:64-79. PMID: 39613048 -
CNS Neurosci Ther
Psilocin suppresses methamphetamine-induced hyperlocomotion and acquisition of conditioned place preference via D2R-mediated ERK signaling. [Abstract]2023 Mar;29(3):831-841. PMID: 36627756 -
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Chem Biol Interact
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells. [Abstract]2024 Apr 1:392:110904. PMID: 38360085 -
Mol Med Rep
Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR‑27b‑3p/ATPase plasma membrane Ca2+ transporting 1 axis. [Abstract]2021 May;23(5):319. PMID: 33760199 -
Sci Rep
Estrogen regulates duodenal calcium absorption and improves postmenopausal osteoporosis by the effect of ERβ on PMCA1b. [Abstract]2025 May 8;15(1):16053. PMID: 40341576 -
BMC Med Genomics
Integrated multi-omic analysis and experiment reveals the role of endoplasmic reticulum stress in lung adenocarcinoma. [Abstract]2024 Jan 2;17(1):12. PMID: 38167084 -
Tohoku J Exp Med
Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1. [Abstract]2022 Jul 22;257(4):315-326. PMID: 35644544 -
Purity & Documentation
References
[1]. Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70. [Content Brief]
[2]. Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. [Content Brief]
[3]. Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545. [Content Brief]
[4]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22. [Content Brief]
[5]. Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trifluoperazine dimaleate Related Classifications
HY-B0532B Related Classifications
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