Trifluoperazine dimaleate
Based on 10 publication(s) in Google Scholar
Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis.
For research use only. We do not sell to patients.
- CAS No.: 605-75-4
- Formula: C29H32F3N3O8S
- Molecular Weight:639.64
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Publications Citing Use of MedChemExpress (MCE) Trifluoperazine dimaleate
More- J Transl Med. 2024 Aug 1;22(1):715. [Abstract]
- Free Radic Biol Med. 2025 Feb 1:227:64-79. [Abstract]
- CNS Neurosci Ther. 2023 Mar;29(3):831-841. [Abstract]
- Food Biosci. 2024 Feb, 57, 103513.
- Chem Biol Interact. 2024 Apr 1:392:110904. [Abstract]
- Mol Med Rep. 2021 May;23(5):319. [Abstract]
- Sci Rep. 2025 May 8;15(1):16053. [Abstract]
- BMC Med Genomics. 2024 Jan 2;17(1):12. [Abstract]
- Tohoku J Exp Med. 2022 Jul 22;257(4):315-326. [Abstract]
- bioRxiv. 2024 June 12.
Customer Validation & Images
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IHC
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IHC
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Cell Proliferation/Viability Assay
All Dopamine Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Description
In Vitro
Trifluoperazine dimaleate is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dimaleate has been an extensively studied drug molecule that has been used as a calmodulin inhibitor[3][4].
Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 605-75-4
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Molecular Weight 639.64
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Formula C29H32F3N3O8S
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SMILES
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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J Transl Med
Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway. [Abstract]2024 Aug 1;22(1):715. PMID: 39090667
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Aug 1;22(1):715. [Abstract]
Representative Masson staining images of mouse knee joints at ×200 magnification (n = 6 mice per group). Scale bar, 50 μm. Mice that underwent DMM received intraperitoneal injections of 1.5 mg/kg TFP (Trifluoperazine dihydrochloride) for 3 days and were euthanized 7 days following DMM.
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Aug 1;22(1):715. [Abstract]
TFP (Trifluoperazine dihydrochloride) treatment significantly lessened synovial hyperplasia, as evidenced by HE staining quantification of synovial thickness.
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Free Radic Biol Med
Zinc ions facilitate metabolic bioenergetic recovery post spinal cord injury by activating microglial mitophagy through the STAT3-FOXO3a-SOD2 pathway. [Abstract]2025 Feb 1:227:64-79. PMID: 39613048 -
CNS Neurosci Ther
Psilocin suppresses methamphetamine-induced hyperlocomotion and acquisition of conditioned place preference via D2R-mediated ERK signaling. [Abstract]2023 Mar;29(3):831-841. PMID: 36627756
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2023 Mar;29(3):831-841. [Abstract]
Effects of TFP‐2HCl (Trifluoperazine dihydrochloride, 2 mg/kg) and SCH772984 on hyperlocomotion induced by acute METH. TFP‐2HCl (Trifluoperazine dihydrochloride) and SCH772984 could inhibit METH‐induced hyperactivity.
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2023 Mar;29(3):831-841. [Abstract]
Administration of 2 mg/kg TFP‐2HCl (Trifluoperazine dihydrochloride) and 10 mg/kg SCH772984 before METH significantly inhibited the increase in CPP score of the METH group (p < 0.01 and p < 0.05, respectively). CPP scores of the groups injected with 2 mg/kg TFP‐2HCl and 10 mg/kg SCH772984 prior to METH were not significantly different from those of the control group.
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Chem Biol Interact
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells. [Abstract]2024 Apr 1:392:110904. PMID: 38360085 -
Mol Med Rep
Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR‑27b‑3p/ATPase plasma membrane Ca2+ transporting 1 axis. [Abstract]2021 May;23(5):319. PMID: 33760199
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 May;23(5):319. [Abstract]
This demonstrated that miR-27b-3p mimics or TFP (Trifluoperazine dihydrochloride) treatment of HUVECs inhibited the cell proliferation, and similar effects were observed on cell migration and tubular formation.
Trifluoperazine dimaleate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 May;23(5):319. [Abstract]
The invasion of trophoblast HTR-8/SVneo cells was again inhibited by the addition of TFP (Trifluoperazine dihydrochloride).
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Sci Rep
Estrogen regulates duodenal calcium absorption and improves postmenopausal osteoporosis by the effect of ERβ on PMCA1b. [Abstract]2025 May 8;15(1):16053. PMID: 40341576 -
BMC Med Genomics
Integrated multi-omic analysis and experiment reveals the role of endoplasmic reticulum stress in lung adenocarcinoma. [Abstract]2024 Jan 2;17(1):12. PMID: 38167084 -
Tohoku J Exp Med
Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1. [Abstract]2022 Jul 22;257(4):315-326. PMID: 35644544 -
Purity & Documentation
References
[1]. Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70. [Content Brief]
[2]. Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. [Content Brief]
[3]. Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545. [Content Brief]
[4]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22. [Content Brief]
[5]. Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trifluoperazine dimaleate Related Classifications
HY-B0532B Related Classifications
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