1. Metabolic Enzyme/Protease
  2. NADPH Oxidase
  3. GLX351322

GLX351322 

Cat. No.: HY-100111 Purity: 99.48%
Handling Instructions

GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

For research use only. We do not sell to patients.

GLX351322 Chemical Structure

GLX351322 Chemical Structure

CAS No. : 835598-94-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    GLX351322 purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Jan 13.

    GLX351322 on the level of phospho-p38 MAPK in VCR-treated cells (*P < .05, NAC/VCR-treated cells compared to VCR-treated cells; GLX351322/VCR-treated cells compared to VCR-treated cells).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

    IC50 & Target

    IC50: 5 μ M (NOX4, cell assay), 40 μM (NOX2, cell assay)[1]

    In Vitro

    GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    431.51

    Formula

    C₂₁H₂₅N₃O₅S

    CAS No.

    835598-94-2

    SMILES

    O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (46.35 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3174 mL 11.5872 mL 23.1744 mL
    5 mM 0.4635 mL 2.3174 mL 4.6349 mL
    10 mM 0.2317 mL 1.1587 mL 2.3174 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.08 mg/mL (4.82 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    GLX351322GLX 351322GLX-351322NADPH OxidaseNOXInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    GLX351322
    Cat. No.:
    HY-100111
    Quantity:
    MCE Japan Authorized Agent: