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GSK2795039 

Cat. No.: HY-18950 Purity: 99.44%
Handling Instructions

GSK2795039 is a novel small molecule NADPH Oxidase 2 Inhibitor.

For research use only. We do not sell to patients.

GSK2795039 Chemical Structure

GSK2795039 Chemical Structure

CAS No. : 1415925-18-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 416 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GSK2795039 is a novel small molecule NADPH Oxidase 2 Inhibitor. target:NADPH Oxidase 2 In vitro: In terms of orthogonal assays, GSK2795039 is not cytotoxic and does not inhibit PKC nor xanthine oxidase at concentrations efficacious for NOX2 inhibition. GSK2795039 inhibits both the formation of ROS and the utilization of the enzyme substrates, NADPH and oxygen, in a variety of semirecombinant cell-free and cell-based NOX2 assays. In vivo: the paw inflammation studies also demonstrate that inhibition of NOX2 by GSK2795039 is reversible since 24 h after administration, when the levels of compound in blood were undetectable, ROS production induced by CFA is similar to that in vehicle-treated animals. The reference doses of GSK2795039 (100 mg/kg) is administered twice via i.p. injection. GSK2795039 causes ~50% reduction in the level of serum amylase activity similar to what is previously reported for gp91phox knockout mice. GSK2795039 is administered in 1% methylcellulose via oral gavage at a dose volume of 10 ml/kg. In mice, 100 mg/kg GSK2795039 is administered in 1% methylcellulose either via oral gavage or i.p. injection at a dose volume of 10 ml/kg.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (71.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2195 mL 11.0973 mL 22.1946 mL
5 mM 0.4439 mL 2.2195 mL 4.4389 mL
10 mM 0.2219 mL 1.1097 mL 2.2195 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

450.56

Formula

C₂₃H₂₆N₆O₂S

CAS No.

1415925-18-6

SMILES

CC(C)N1C=C(C2=CC=C(CCN3C)C3=C2)C4=C1N=CC=C4NS(C5=NN(C)C=C5)(=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.44%

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Product Name:
GSK2795039
Cat. No.:
HY-18950
Quantity:

GSK2795039

Cat. No.: HY-18950