1. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  2. NADPH Oxidase Reactive Oxygen Species Apoptosis
  3. GSK2795039

GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.

For research use only. We do not sell to patients.

GSK2795039 Chemical Structure

GSK2795039 Chemical Structure

CAS No. : 1415925-18-6

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 310 In-stock
25 mg USD 550 In-stock
50 mg USD 800 In-stock
100 mg USD 1200 In-stock
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Customer Review

Based on 49 publication(s) in Google Scholar

Top Publications Citing Use of Products

48 Publications Citing Use of MCE GSK2795039

RT-PCR

    GSK2795039 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2019 Dec 24;29(13):4435-4446.e9.   [Abstract]

    GSK2795039 (2 μM) blocks annexin-induced ROSs.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption[1]. GSK2795039 reduces apoptosis[2].

    IC50 & Target

    NOX2

     

    In Vitro

    GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Apoptosis Analysis[2]

    Cell Line: PC12 cells
    Concentration: 25 μM
    Incubation Time: 24 hours
    Result: Reduced apoptosis among PC12 cells.
    In Vivo

    GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL6 mice[1]
    Dosage: 100 mg/kg
    Administration: Intraperitoneal injection; 100 mg/kg; 1 hour before
    Result: Caused 50% reduction in the level of serum amylase activity.
    Molecular Weight

    450.56

    Formula

    C23H26N6O2S

    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    CC(C)N1C=C(C2=CC=C(CCN3C)C3=C2)C4=C1N=CC=C4NS(C5=NN(C)C=C5)(=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (221.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2195 mL 11.0973 mL 22.1946 mL
    5 mM 0.4439 mL 2.2195 mL 4.4389 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months. When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  20% DMSO, 20% Tween 80, 60% polyethylene glycol 200

      Solubility: 10 mg/mL (22.19 mM); Clear solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 6.67 mg/mL (14.80 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.71%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months. When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2195 mL 11.0973 mL 22.1946 mL 55.4865 mL
    5 mM 0.4439 mL 2.2195 mL 4.4389 mL 11.0973 mL
    10 mM 0.2219 mL 1.1097 mL 2.2195 mL 5.5487 mL
    15 mM 0.1480 mL 0.7398 mL 1.4796 mL 3.6991 mL
    20 mM 0.1110 mL 0.5549 mL 1.1097 mL 2.7743 mL
    25 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
    30 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8496 mL
    40 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
    50 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1097 mL
    60 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9248 mL
    80 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
    100 mM 0.0222 mL 0.1110 mL 0.2219 mL 0.5549 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    GSK2795039
    Cat. No.:
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