1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. NADPH Oxidase
    Reactive Oxygen Species
  3. GSK2795039

GSK2795039 

Cat. No.: HY-18950 Purity: 98.14%
Handling Instructions

GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.

For research use only. We do not sell to patients.

GSK2795039 Chemical Structure

GSK2795039 Chemical Structure

CAS No. : 1415925-18-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 416 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 13 publication(s) in Google Scholar

Top Publications Citing Use of Products

    GSK2795039 purchased from MCE. Usage Cited in: Cell Rep. 2019 Dec 24;29(13):4435-4446.e9. 

    GSK2795039 (2 μM) blocks annexin-induced ROSs.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption[1]. GSK2795039 reduces apoptosis[2].

    In Vitro

    GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells[2].

    Apoptosis Analysis[2]

    Cell Line: PC12 cells
    Concentration: 25 μM
    Incubation Time: 24 hours
    Result: Reduced apoptosis among PC12 cells.
    In Vivo

    GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein[1].

    Animal Model: C57BL6 mice[1]
    Dosage: 100 mg/kg
    Administration: Intraperitoneal injection; 100 mg/kg; 1 hour before
    Result: Caused 50% reduction in the level of serum amylase activity.
    Molecular Weight

    450.56

    Formula

    C₂₃H₂₆N₆O₂S

    CAS No.

    1415925-18-6

    SMILES

    CC(C)N1C=C(C2=CC=C(CCN3C)C3=C2)C4=C1N=CC=C4NS(C5=NN(C)C=C5)(=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (71.02 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2195 mL 11.0973 mL 22.1946 mL
    5 mM 0.4439 mL 2.2195 mL 4.4389 mL
    10 mM 0.2219 mL 1.1097 mL 2.2195 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.14%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    GSK2795039GSK 2795039GSK-2795039NADPH OxidaseReactive Oxygen SpeciesNOXInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    GSK2795039
    Cat. No.:
    HY-18950
    Quantity:
    MCE Japan Authorized Agent: