19132-12-8
Chemical Structure
Dihydronicotinamide riboside
- CAS No.: 19132-12-8
- Formula:C11H16N2O5
- Molecular Weight:256.26
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydropyridine-3-carboxamide
InChIKey: MAKBMGXNXXXBFE-TURQNECASA-N
SMILES: NC(C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=CC1)=O
Biological Activity: Dihydronicotinamide riboside is a potent NAD+ concentration enhancer. Dihydronicotinamide riboside modulates targets BAX, PUMA, NQO2, and IκB kinase. Dihydronicotinamide riboside mediates apoptosis, induces pro-oxidant activity, mitochondrial dysfunction, metabolic dysregulation, redox modulation, and pro-inflammatory M1 phenotype induction. Dihydronicotinamide riboside increases intracellular and mitochondrial NAD+ levels, maintains cell survival against NAD+-depleting genotoxins. Dihydronicotinamide riboside can be used for the research of hepatocellular carcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydronicotinamide riboside | 95.0% | Dihydronicotinamide riboside is a potent NAD+ concentration enhancer. Dihydronicotinamide riboside modulates targets BAX, PUMA, NQO2, and IκB kinase. Dihydronicotinamide riboside mediates apoptosis, induces pro-oxidant activity, mitochondrial dysfunction, metabolic dysregulation, redox modulation, and pro-inflammatory M1 phenotype induction. Dihydronicotinamide riboside increases intracellular and mitochondrial NAD+ levels, maintains cell survival against NAD+-depleting genotoxins. Dihydronicotinamide riboside can be used for the research of hepatocellular carcinoma. | ||||||||||||||||||||
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References
- [1]. Sonavane M, et al. Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress. PLoS One. 2020;15(11):e0242174. Published 2020 Nov 9. [Content Brief]
- [2]. Yang Y, et al. Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo. J Biol Chem. 2019 Jun 7;294(23):9295-9307. [Content Brief]
- [3]. Chini CCS, et al. Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages. Front Immunol. 2022;13:840246. Published 2022 Feb 25. [Content Brief]
