1. Metabolic Enzyme/Protease
  2. NADPH Oxidase
  3. APX-115

APX-115 (Synonyms: Ewha-18278)

Cat. No.: HY-120801
Handling Instructions

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice.

For research use only. We do not sell to patients.

APX-115 Chemical Structure

APX-115 Chemical Structure

CAS No. : 1395946-75-4

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Description

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1].

IC50 & Target

Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]

Molecular Weight

315.80

Formula

C₁₇H₁₈ClN₃O

CAS No.

1395946-75-4

SMILES

OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3.Cl

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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APX-115
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