1. Metabolic Enzyme/Protease
  2. NADPH Oxidase
  3. APX-115

APX-115 (Synonyms: Ewha-18278)

Cat. No.: HY-120801 Purity: >98.0%
Handling Instructions

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.

For research use only. We do not sell to patients.

APX-115 Chemical Structure

APX-115 Chemical Structure

CAS No. : 1395946-75-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1164 In-stock
Estimated Time of Arrival: December 31
1 mg USD 335 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of APX-115:

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Description

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1].

IC50 & Target

Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]

Molecular Weight

315.80

Formula

C₁₇H₁₈ClN₃O

CAS No.

1395946-75-4

SMILES

OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (791.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1666 mL 15.8328 mL 31.6656 mL
5 mM 0.6333 mL 3.1666 mL 6.3331 mL
10 mM 0.3167 mL 1.5833 mL 3.1666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
APX-115
Cat. No.:
HY-120801
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