2. Metabolic Enzyme/Protease
  3. NADPH Oxidase
  4. APX-115

APX-115  (Synonyms: Ewha-18278)

Cat. No.: HY-120801 Purity: 99.58%
COA Handling Instructions

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.

For research use only. We do not sell to patients.

APX-115 Chemical Structure

APX-115 Chemical Structure

CAS No. : 1395946-75-4

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of APX-115:

APX-115 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE APX-115

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1].

IC50 & Target

NOX1

 

NOX2

 

NOX4

 

In Vitro

APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line[2].
In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

APX-115 Related Antibodies
In Vivo

APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[2].
APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male diabetic db/db mice (C57BLKS/J-leprdb/leprdb)[2]
Dosage: 60 mg/kg
Administration: Oral gavage; per day; for 12 weeks
Result: Significantly improved insulin resistance in diabetic mice.
Clinical Trial
Molecular Weight

315.80

Appearance

Solid

Formula

C17H18ClN3O
CAS No.
SMILES

OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (316.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1666 mL 15.8328 mL 31.6656 mL
5 mM 0.6333 mL 3.1666 mL 6.3331 mL
10 mM 0.3167 mL 1.5833 mL 3.1666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.58%

COA (254 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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APX-115 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

APX-1151395946-75-4Ewha-18278APX115APX 115Ewha18278Ewha 18278NADPH OxidaseNOXNox1Nox2Nox3kidneyinjuryinsulinresistancealbuminplasmacreatinineInhibitorinhibitorinhibit

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