2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. NADPH Oxidase Interleukin Related Apoptosis
  4. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium  (Synonyms: 18:1 Lyso-PS)

Cat. No.: HY-126213 Purity: 99.0%
COA
SDS
Handling Instructions Technical Support

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following NADPH oxidase activation and Lyso-PS signal transduction. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium signals through macrophage G2A to enhance the phagocytic uptake of PS-dependent apoptotic (apoptosis) neutrophils and PS-exposed activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium enhances macrophage phagocytic uptake of apoptotic cells, carboxylate-modified microspheres, and PS-exposed non-apoptotic activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium serves as an acyl acceptor substrate for the lysophosphatidyltransferase At1g78690p to generate diacylphosphatidylserine. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium reduces the secretion of IL-8 and decreases the proportion of viable colon cancer cells. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium is applicable to studies on peritonitis and inflammatory bowel disease.

For research use only. We do not sell to patients.

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium Chemical Structure

CAS No. : 326589-90-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium Related Antibodies

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  • Biological Activity

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Description

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following NADPH oxidase activation and Lyso-PS signal transduction. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium signals through macrophage G2A to enhance the phagocytic uptake of PS-dependent apoptotic (apoptosis) neutrophils and PS-exposed activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium enhances macrophage phagocytic uptake of apoptotic cells, carboxylate-modified microspheres, and PS-exposed non-apoptotic activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium serves as an acyl acceptor substrate for the lysophosphatidyltransferase At1g78690p to generate diacylphosphatidylserine. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium reduces the secretion of IL-8 and decreases the proportion of viable colon cancer cells. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium is applicable to studies on peritonitis and inflammatory bowel disease[1][2][3].

In Vitro

Pretreatment of RAW264.7 macrophages with 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (30 mol%; 1 h) increases the phagocytosis of COOH-modified apoptotic cell mimics by approximately 70%[1].
1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (2 mM; 160 min at 37°C) serves as an efficient substrate for At1g78690p from *Arabidopsis thaliana* expressed in E. coli BLR (DE3) pLysS[2].
1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (0-33 μM; 24 h)
reduces the viability of human colon carcinoma-derived epithelial HT-29 cells, but exerts no significant effect in the presence of LPS[3].
1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (0-33 μM; 24 h) reduces interleukin-8 secretion in human colon carcinoma-derived epithelial cell line HT-29 under LPS-free conditions, but exerts no significant effect in the presence of LPS[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium Related Antibodies

Cell Viability Assay[3]

Cell Line: human colon cancer-derived epithelial HT-29 cells
Concentration: 0.33, 1, 3.3, 10, 33 μM
Incubation Time: 24 h
Result: Decreased cell viability to a relative ratio of 0.81 at 33 μM in the absence of LPS.
Did not significantly alter cell viability at 33 μM in the presence of LPS.

ELISA Assay[3]

Cell Line: human colon cancer-derived epithelial HT-29 cells
Concentration: 0.33, 1, 3.3, 10, 33 μM
Incubation Time: 24 h
Result: Decreased IL-8 secretion to a relative ratio of 0.81 at 33 μM in the absence of LPS.
Did not significantly alter IL-8 secretion at any tested concentration in the presence of LPS.
Molecular Weight

545.58

Formula

C24H45NNaO9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COP(O)(OC[C@H](O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (183.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8329 mL 9.1646 mL 18.3291 mL
5 mM 0.3666 mL 1.8329 mL 3.6658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.0%

SDS (252 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8329 mL 9.1646 mL 18.3291 mL 45.8228 mL
5 mM 0.3666 mL 1.8329 mL 3.6658 mL 9.1646 mL
10 mM 0.1833 mL 0.9165 mL 1.8329 mL 4.5823 mL
15 mM 0.1222 mL 0.6110 mL 1.2219 mL 3.0549 mL
20 mM 0.0916 mL 0.4582 mL 0.9165 mL 2.2911 mL
25 mM 0.0733 mL 0.3666 mL 0.7332 mL 1.8329 mL
30 mM 0.0611 mL 0.3055 mL 0.6110 mL 1.5274 mL
40 mM 0.0458 mL 0.2291 mL 0.4582 mL 1.1456 mL
50 mM 0.0367 mL 0.1833 mL 0.3666 mL 0.9165 mL
60 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.7637 mL
80 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.5728 mL
100 mM 0.0183 mL 0.0916 mL 0.1833 mL 0.4582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine326589-90-618:1 Lyso-PSNADPH OxidaseInterleukin RelatedApoptosisNOXILcolon cancer epithelial cellapoptotic neutrophilsG2A receptorneutrophilic inflammationinterleukin-8di-acyl phosphatidylserinemacrophagelysophospholipid acyltransferase At1g78690pRAW264.7 macrophagesactivated PS-exposing neutrophilsPS productperitonitisinflammatory bowel diseaseInhibitorinhibitorinhibit

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