1632125-79-1
Chemical Structure
ML345
- CAS No.: 1632125-79-1
- Formula:C21H22FN3O5S2
- Molecular Weight:479.54
IUPAC Name: 5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one
InChIKey: FVKOFZKSMMIUTL-UHFFFAOYSA-N
SMILES: O=C1C2=C(SN1C3=CC(S(N4CCOCC4)(=O)=O)=CC=C3N5CCOCC5)C=CC(F)=C2
Biological Activity: ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage[1][2].
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ML345 | 99.37% | ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage. | ||||||||||||||||||||
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- [1]. Lin H, et al. ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity. Mol Biomed. 2025;6(1):108. Published 2025 Nov 13. [Content Brief]
- [2]. Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE). In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); December 17, 2012. [Content Brief]
Keywords
