CCR8 Protein-VLP, Human (HEK293)
Based on 1 Customer Validation
CCR8 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CCR8 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.
Background
The CCR8 Protein-VLP acts as a receptor for the chemokine CCL1/SCYA1/I-309, potentially regulating monocyte chemotaxis and thymic cell line apoptosis. It also serves as an alternative coreceptor with CD4 for HIV-1 infection, implicating its involvement in facilitating viral entry and infection. The interaction between CCR8 and CCL1 underscores its role in mediating cellular responses to this chemokine, suggesting a regulatory function in immune and inflammatory processes.
Verified Bioactivity
1.Immobilized Human CCR8 VLP at 5 μg/mL (100 μL/Well) on the plate. Dose response curvefor Anti-CCR8 Antibody, hFc Tag with the EC50 of 6-7 ng/mL determined by ELISA.
2.Loaded Lanerkitug (HY-P991942) on ACH2 biosensor, can bind CCR8 Protein-VLP, Human (HEK293) with an affinity constant of 3.909E-08 M as determined in BLI assay.
MCE Validation Data
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Bioactivity - BLI
Bioactivity - BLI
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
P51685 (M1-L355)
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Molecular Construction
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N-term
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CCR8-VLP (M1-L355)
Accession # P51685 -
C-term
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Protein Length
Full Length
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Synonyms
CCR8; Chemokine Receptor-Like 1; Prev. CMKBRL2; GPRCY6; Prev. CMKBR8; CCR-8; TER1; CKRL1; C-C Chemokine Receptor Type 8; Chemokine (C-C) Receptor-Like 2; GPR-CY6; CC-Chemokine Receptor Chemr1; CKR-L1; Chemokine (C-C) Receptor 8; CDw198; CC Chemokine Recep
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AA Sequence
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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Predicted Molecular Mass
44.1 kDa
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Purity
≥ 95%, as determined by HPLC.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, 300 mM L-arginine, pH 7.4. Notice: If you need it for immunization, water-soluble adjuvant is recommended.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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