2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. Lanerkitug

Lanerkitug  (Synonyms: BAY3375968; TPP-23411)

Cat. No.: HY-P991942
Technical Support

Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8+ Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors.

For research use only. We do not sell to patients.

Lanerkitug

Lanerkitug Chemical Structure

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This product is a controlled substance and not for sale in your territory.

Other Forms of Lanerkitug:

Lanerkitug Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8+ Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors[1][2].

Species Reactivity

Human
IC50 & Target[1]

CCR8

 

In Vitro

Lanerkitug (0.001 pM-10000 pM; 2-4 h) mediates potent Fc-dependent ADCC of human CCR8-expressing HEK293 cells and primary human activated Tregs (EC50 = 0.35-0.48 pM)[1].
Lanerkitug selectively deplets human CCR8+ Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lanerkitug Related Antibodies
In Vivo

Lanerkitug shows a good safety profile in cynomolgus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Gene ID

1237  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lanerkitug Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LanerkitugBAY3375968 TPP-23411BAY 3375968BAY-3375968TPP23411TPP 23411TPP-23411CCRCC chemokine receptorADCPcancer modelstumor microenvironmentphagocytosisTregsCD8+ T cellADCCantibody-dependent cellular cytotoxicityCCR8immune checkpoint inhibitorsInhibitorinhibitorinhibit

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