Lanerkitug
Based on 1 Customer Validation
Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8+ Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors.
For research use only. We do not sell to patients.
- Purity: 97.00%
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 lambda2
Human
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CCR8 |
Lanerkitug (0.001 pM-10000 pM; 2-4 h) mediates potent Fc-dependent ADCC of human CCR8-expressing HEK293 cells and primary human activated Tregs (EC50 = 0.35-0.48 pM)[1].
Lanerkitug selectively deplets human CCR8+ Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Loaded Lanerkitug on ACH2 biosensor, can bind HY-P77882 CCR8 Protein-VLP, Human (HEK293) with an affinity constant of 3.909E-08 M as determined in BLI assay.
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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Synonyms
BAY3375968; TPP-23411
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)