Fumonisin B1-13C34
Based on 1 Customer Validation
Fumonisin B1-13C34 is the 13C labeled Fumonisin B1 (HY-N6719). Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
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- Pureté : 98.5%
- CAS No.: 1217458-62-2
- Formule: 13C34H59NO15
- Masse moléculaire:755.58
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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(S)-Propane-1,2,3-triyl tripalmitate-d9Stable Isotope
Activité biologique
Description
IC50 & Target
Sphingosine N-acyltransferase[2]
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[2].
Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217458-62-2
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Unlabeled CAS 116355-83-0
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Appearance Liquid
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Masse moléculaire 755.58
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Formule 13C34H59NO15
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Color Colorless to light yellow
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SMILES
O[13C]([13CH2][13C@@H]([13C](O)=O)[13CH2][13C](O[13C@@H]([13CH2][13C@@H]([13CH3])[13CH2][13C@H](O)[13CH2][13CH2][13CH2][13CH2][13C@@H](O)[13CH2][13C@H](O)[13C@@H](N)[13CH3])[13C@@H]([13C@H]([13CH3])[13CH2][13CH2][13CH2][13CH3])O[13C]([13CH2][13C@H]([13C](O)=O)[13CH2][13C](O)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (276 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. [Content Brief]
[2]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [Content Brief]
[3]. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fumonisin B1-13C34 Related Classifications
HY-N6719S Related Classifications
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