Isotope-Labeled Sphingolipids
- Formula: C34H58D9NO3
- Molecular Weight: 546.96
C16-Ceramide-d9 is deuterium labeled C16-Ceramide.
- Formula: C18H30D7NO2
- Molecular Weight: 306.54
D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
- Formula: C36H64D7NO3
- Molecular Weight: 573.00
C18-Ceramide-d7 is deuterium labeled C18-Ceramide.
- Formula: C18H31D7NO5P
- Molecular Weight: 386.51
Sphingosine-1-phosphate-d7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.
- Formula: C34H36D31NO3
- Molecular Weight: 569.09
C16-Ceramide-d31 is deuterium labeled C16-Ceramide.
- Formula: C1813C18H69NO3
- Molecular Weight: 581.81
C18:1-Ceramide-13C18 is a 13C-labeled C18:1-Ceramide (HY-141578). C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes.
- Formula: C42H74D7NO3
- Molecular Weight: 655.14
C24:1-Ceramide-d7 is the deuterium labeled C24:1-Ceramide.
- Formula: C18H32D7NO2
- Molecular Weight: 308.55
D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
- Formula: C42H76D7NO3
- Molecular Weight: 657.16
C24-Ceramide-d7 is the deuterium labeled C24-Ceramide.
- Formula: C39H70D9N2O6P
- Molecular Weight: 712.08
N-Palmitoyl-D-sphingomyelin-d9 (Sphingomyelin 16:0-d9) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.
- Formula: C24H42D5NO7
- Molecular Weight: 466.66
Glucosylsphingosine-d5 is the deuterium labeled Glucosylsphingosine.
- Formula: C24H40D7NO7
- Molecular Weight: 468.68
Glucosylsphingosine-d7 is deuterium labeled Glucosylsphingosine.
- Formula: C24H42D5NO7
- Molecular Weight: 466.66
Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.
- Formula: C49H95D4N2O6P
- Molecular Weight: 847.32
C26 Sphingomyelin (d18:1/26:0)-d4 is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.
- Formula: C34H60D9NO4
- Molecular Weight: 564.97
CER3-d9 is deuterium labeled CER3.
- Formula: C34H60D9NO3
- Molecular Weight: 548.97
CER10-d9 is deuterium labeled CER10.
- Formula: C40H74D3NO8
- Molecular Weight: 703.06
D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-CD3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity.
- Formula: C3413C2H69D2NO3
- Molecular Weight: 569.95
C18-Ceramide-13C2,d2 is a deuterated labeled C18-Ceramide-13C2,d2.
- Formula: C1813C6H47NO7
- Molecular Weight: 467.59
Glucosylsphingosine-13C6 (Glucopsychosine-13C6) is the 13C-labeled Glucosylsphingosine (HY-N7745). Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a Ki value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease.
- Formula: C41H72D9N2O6P
- Molecular Weight: 738.12
18:1 SM (d18:1/18:1)-d9 is deuterium labeled 18:1 SM (d18:1/18:1).
