Isotope-Labeled Sphingolipids

CER3-d₉ is deuterium labeled CER3.

CER10-d₉ is deuterium labeled CER10.

C22 Glucosylceramide (d18:1/22:0)-d₄ is deuterium labeled C22 Glucosylceramide (d18:1/22:0) (HY-164236). C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields.

C18 Dihydroceramide-d₃-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d₃) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product.

16:1 SM (d18:1/16:1)-d₉ is deuterium labeled 16:1 SM (d18:1/16:1).

18:1 SM (d18:1/18:1)-d₉ is deuterium labeled 18:1 SM (d18:1/18:1).

D-Glucosyl-β-N-palmitoylsphingosine-d₃ (N-ω-CD₃-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity.

C18-Ceramide-13C2,d2 is a deuterated labeled C18-Ceramide-13C2,d2.

Glucosylsphingosine-¹³C₆ (Glucopsychosine-¹³C₆) is the ¹³C-labeled Glucosylsphingosine (HY-N7745). Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a K_i value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease.

24:1 SM (d18:1/24:1)-d₉ is deuterium labeled 24:1 SM (d18:1/24:1).

Sphingosine-d₉ (d₁₈:1) (D-eytho-Sphigosie C18-d₉) is deuterium labeled Sphingosine (d18:1).

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

C15-Ceramide-d₇ is deuterium labeled C15-Ceramide. C15-Ceramide is an ester product.

Sphingosylphosphorylcholine-d₇ is the deuterium labeled Sphingosylphosphorylcholine (HY-132187).

Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells.

Ceramide C6-d₇ is the deuterium labeled Ceramide C6. Ceramide C6, a Ceramide pathway activator, is an exogenous short-chain ceramide which can induce apoptosis of multiple cancer cells.

Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia.

4E,14Z-Sphingadiene-d₇ is deuterium labeled 4E,14Z-Sphingadiene.

Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.