C22 Glucosylceramide (d18:1/22:0) 

C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields^[1][2][3].

C22 Glucosylceramide (d18:1/22:0) is not detected in either parental or Doxorubicin (HY-15142A)-resistant MCF-7 human breast adenocarcinoma cells in this sphingolipidomic analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

The in vivo levels of C22 Glucosylceramide (d18:1/22:0) are significantly affected by various dietary and nutritional interventions: intake of a diet rich in saturated fatty acids increases the concentration of C22 Glucosylceramide (d18:1/22:0) in postprandial HDL (high-density lipoprotein), while supplementation with milk-derived polar lipids or Korean red ginseng effectively reduces its concentration in chylomicrons or plasma in different study populations, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

784.20

C₄₆H₈₉NO₈

119242-44-3

Solid

White to off-white

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO

Room temperature in continental US; may vary elsewhere.

• [1]. Shammout ODA, et al. Comparative sphingolipidomic analysis reveals significant differences between doxorubicin-sensitive and -resistance MCF-7 cells. PLoS One. 2021;16(10):e0258363. Published 2021 Oct 12.

  [2]. Calzada C, et al. Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter. Front Nutr. 2023;9:1108098. Published 2023 Jan 11.

  [3]. Kwon YJ, et al. Effect of Korean Red Ginseng on Plasma Ceramide Levels in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial. Metabolites. 2021;11(7):417. Published 2021 Jun 24.