Glucosylceramide (gaucher's spleen)
Based on 1 Customer Validation
Glucosylceramide (Glucocerebrosides) (gaucher's spleen) is a glycosphingolipid and primary substrate of acid β-glycosidase, suppresses tyrosine phosphorylation of insulin receptor and IRS-1, disrupts insulin signaling cascade and triggers pancreatic β-cell dysfunction. Glucosylceramide (Gaucher's spleen) accumulates in rodents and induces obesity and insulin resistance, restores systemic glucose homeostasis and insulin sensitivity when synthesis is suppressed. Glucosylceramide (Gaucher's spleen) accumulates in the brain of chronic neuronopathic Gaucher disease mice with age and can be applied for research on insulin resistance, type 2 diabetes mellitus and chronic neuronopathic Gaucher disease.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 85305-87-9
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Glucosylceramide (Gaucher's spleen) causes sustained cerebral accumulation, which triggers insoluble α-synuclein aggregation in the cerebral cortex and hippocampus, impairs hippocampus-dependent contextual and cued fear memory, and induces short-term spatial memory deficits starting at 9 months old[2].
Glucosylceramide (Gaucher's spleen) accumulates in the spleen and liver of 9V/null mice and induces age-dependent hepatosplenomegaly[2].
Glucosylceramide (Gaucher's spleen) overload alters gait parameters including fore/hind paw base width and stride length, leading to sensorimotor dysfunction[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 85305-87-9
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Appearance Solid
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Color White to off-white
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SMILES
O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O)OC[C@H](NC([R])=O)[C@@H](/C=C/CCCCCCCCCCCCC)O)CO)O
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Synonyms
Glucocerebrosides; Gaucher cerebroside; GluCers (gaucher's spleen)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Holland WL, et al. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocrine reviews. 2008 Jun;29(4):381-402. [Content Brief]
[3]. Cahoon EB, et al. Analysis of Glucocerebrosides of Rye (Secale cereale L. cv Puma) Leaf and Plasma Membrane. Plant Physiol. 1991 Jan;95(1):58-68. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucosylceramide (gaucher's spleen) Related Classifications
HY-165035 Related Classifications
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- Glucosylceramide (gaucher's spleen)
- 85305-87-9
- Glucocerebrosides
- Gaucher cerebroside
- GluCers (gaucher's spleen)
- Endogenous Metabolite
- Glycosidase
- Insulin Receptor
- rye
- β-cell apoptosis
- Gaucher's disease
- chronic neuronopathic Gaucher Disease mouse model
- IRS-1
- insulin receptor
- pancreatic β-cell
- acid β-glucosidase
- rodent models
- type 2 diabetes
- Inhibitor
- inhibitor
- inhibit