Glucosylceramide, plant
Based on 1 Customer Validation
Glucosylceramide, plant (GluCer (Soy)) is an orally active, plant-derived glucosylceramide. Glucosylceramide, plant inhibits lipopolysaccharide-induced cytokine production and Apoptosis. Glucosylceramide, plant suppresses DSS-induced body weight loss, colonic crypt damage and intestinal inflammation in mice. Glucosylceramide, plant can be used in research related to inflammatory bowel disease and colon cancer.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 497155-61-0
- Formula: C40H75NO9
- Molecular Weight:714.02
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Glucosylceramide, plant suppresses lipopolysaccharide-induced cytokine production and apoptosis in differentiated Caco-2 cells, exerting potent anti-inflammatory and cytoprotective effects regardless of sphingoid base composition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 4 weeks old, DSS-induced colitis)[1]
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Dosage:0.1% (1 g/kg diet)
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Administration:p.o.; daily; 5 or 15 days
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Result:Suppressed DSS-induced body weight loss in the early phase of treatment.
Reduced DSS-induced chorionic crypt injury observed via toluidine blue-stained colon histology.
Significantly suppressed DSS-elevated myeloperoxidase levels, which were approximately 2-fold higher in DSS-only controls compared to untreated mice.
Normalized DSS-induced increases in inflammatory cytokines (IL-1α, IL-1β, IL-16), chemokines (MIG, IP-10), and adhesion molecules (C5/C5a, sICAM-1) to levels similar to untreated mice.
Chemical Information
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CAS No. 497155-61-0
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Appearance Solid
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Molecular Weight 714.02
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Formula C40H75NO9
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Color White to off-white
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SMILES
[H][C@](/C=C/CC/C=C/CCCCCCCCC)(O)[C@@]([H])(NC(C(O)CCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
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Synonyms
GluCer (Soy)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Arai K, et al. Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice. Journal of oleo science. 2015;64(7):737-42. [Content Brief]
[2]. Yamashita S, et al. Chemical Properties and Nutritional Value of Plant-Origin Glucosylceramide. Journal of nutritional science and vitaminology. 2019;65(Supplement):S153-S157. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucosylceramide, plant Related Classifications
HY-W717504 Related Classifications
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