C22 Glucosylceramide (d18:1/22:0)-d4
Based on 1 Customer Validation
C22 Glucosylceramide (d18:1/22:0)-d4 is deuterium labeled C22 Glucosylceramide (d18:1/22:0) (HY-164236). C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 2738376-81-1
- Formula: C46H85D4NO8
- Molecular Weight:788.23
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2738376-81-1
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Unlabeled CAS 119242-44-3
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Appearance Solid
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Molecular Weight 788.23
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Formula C46H85D4NO8
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Color White to off-white
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SMILES
O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O)OC[C@H](NC(CCCCCCCCCCC([2H])(C([2H])(CCCCCCCCC)[2H])[2H])=O)[C@@H](/C=C/CCCCCCCCCCCCC)O)CO)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Shammout ODA, et al. Comparative sphingolipidomic analysis reveals significant differences between doxorubicin-sensitive and -resistance MCF-7 cells. PLoS One. 2021;16(10):e0258363. Published 2021 Oct 12. [Content Brief]
[3]. Calzada C, et al. Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter. Front Nutr. 2023;9:1108098. Published 2023 Jan 11. [Content Brief]
[4]. Kwon YJ, et al. Effect of Korean Red Ginseng on Plasma Ceramide Levels in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial. Metabolites. 2021;11(7):417. Published 2021 Jun 24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C22 Glucosylceramide (d18:1/22:0)-d4 Related Classifications
HY-164236S Related Classifications
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