Isotope-Labeled Neutral Glycosphingolipids
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- Formula: C24H42D5NO7
- Molecular Weight: 466.66
Glucosylsphingosine-d5 is the deuterium labeled Glucosylsphingosine.
- Formula: C24H40D7NO7
- Molecular Weight: 468.68
Glucosylsphingosine-d7 is deuterium labeled Glucosylsphingosine.
- Formula: C42H76D5NO8
- Molecular Weight: 733.13
C18 Glucosyl(ß) ceramide-d5 is deuterium labeled C18 Glucosyl(ß) ceramide.
- Formula: C46H85D4NO8
- Molecular Weight: 788.23
C22 Glucosylceramide (d18:1/22:0)-d4 is deuterium labeled C22 Glucosylceramide (d18:1/22:0) (HY-164236). C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields.
- Formula: C40H74D3NO8
- Molecular Weight: 703.06
D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-CD3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity.
- Formula: C54H98D3NO18
- Molecular Weight: 1055.39
C18 Globotriaosylceramide-d3 is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product.
- Formula: C39H68D7NO8
- Molecular Weight: 693.06
C15 Glucosyl(β) ceramide-d7 is deuterium labeled C15 Glucosyl(β) ceramide.
- Formula: C84H141D7N4O39
- Molecular Weight: 1845.12
C18:0-d7 GD1b Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD1b Ceramide (d18:1/18:0).
- Formula: C1813C6H47NO7
- Molecular Weight: 467.59
Glucosylsphingosine-13C6 (Glucopsychosine-13C6) is the 13C-labeled Glucosylsphingosine (HY-N7745). Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a Ki value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease.
- Formula: C62H107D7N2O23
- Molecular Weight: 1262.61
C18:0-d7 GB4 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GB4 Ceramide (d18:1/18:0).
- Formula: C42H46D35NO8
- Molecular Weight: 763.31
β-Galactosyl-C18-ceramide-d35 is deuterium labeled β-Galactosyl-C18-ceramide. β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.
- Formula: C42H74D5NO8
- Molecular Weight: 731.11
C18:1 Glucosyl ceramide-d5 is deuterium labeled C18:1 Glucosyl ceramide.
- Formula: C52H88D9NO18
- Molecular Weight: 1033.38
Gb3(d18:1/16:0)-d9 is deuterium labeled Gb3(d18:1/16:0) (HY-156209). Gb3 (d18:1/16:0) (Compound 1) is the Pk antigen of the P blood group system. Gb3 (d18:1/16:0) acts as a cell surface receptor. Gb3 (d18:1/16:0) is used for research on Burkitt's lymphoma, teratocarcinoma, embryonal carcinoma, and Fabry's disease.
- Formula: C46H85D4NO8
- Molecular Weight: 788.23
C22 Galactosylceramide-d4 is deuterium labeled C22 Galactosylceramide. C22 Galactosylceramide is a sphingolipid present in the central nervous system, exhibiting elevated levels in the spinal cord of mice on a methionine-restricted diet, while not affecting the brain or liver; furthermore, it has been identified in the postmortem hippocampus of Alzheimer's disease patients.
- Formula: C78H131D7N4O34
- Molecular Weight: 1682.98
C18:0-d7 GD2 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD2 Ceramide (d18:1/18:0).
- Formula: C54H94D7NO18
- Molecular Weight: 1059.42
Gb3-d7 (18:1/18:0) (C18 Globotriaosylceramide-d7 (d18:1/18:0)) is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product.
- Formula: C46H84D3NO13
- Molecular Weight: 865.20
LacCer (d18:1/16:0) (C16 Lactosylceramide (d18:1/16:0))-d3 is the deuterium labeled LacCer (d18:1/16:0) (HY-153830). LacCer (d18:1/16:0) is an endogenous bioactive sphingolipid that can form membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs). LacCer (d18:1/16:0) are elevated in the plasma of insulin-resistant cattle. LacCer (d18:1/16:0) is also upregulated in a mouse model of Niemann-Pick type C1 disease (a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder). LacCer (d18:1/16:0) can be used in research on metabolic diseases and neurodegenerative diseases.
- Formula: C54H94D7NO13
- Molecular Weight: 979.42
D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
- Formula: C48H84D7NO8
- Molecular Weight: 817.28
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
- Formula: C70H118D7N3O29
- Molecular Weight: 1479.79
C18:0-d7 GD3 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD3 Ceramide (d18:1/18:0).
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