C18:1-Ceramide
Based on 1 Customer Validation
C18:1-Ceramide is a ceramide subspecies belonging to bioactive lipids. C18:1-Ceramide exhibits activities of inducing skeletal muscle insulin resistance and affecting metabolism. C18:1-Ceramide can be used in the research of obesity, type 2 diabetes (T2D), insulin resistance and other related metabolic diseases.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 5966-28-9
- Formula: C36H69NO3
- Molecular Weight:563.94
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-100354
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C18-Ceramide (d18:1/18:0) -
HY-134575
C24:1-Ceramide -
HY-154831
C22-Ceramide (d18:1/22:0) -
HY-112016
C20 Ceramide (d18:1/20:0) -
HY-101180
C2 Ceramide -
HY-141629
N-Palmitoyl-D-sphingomyelin -
HY-134508
C24-Ceramide -
HY-141578R
C18:1-Ceramide (Standard) -
HY-W923646
C24:1-Dihydro-ceramide -
HY-N7092S
D-Fructose-13C6 -
HY-113378S
3-Hydroxybutyric acid-d4 sodium
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
C18:1-Ceramide (0.5 μM; 2-12 h) enhances LPS (HY-D1056)-induced expression of IL-1β, IL-23a, IL-6 and TNF-α in mouse blood monocytes[3].
The level of C18:1-Ceramide is increased in Acer3-deficient mouse primary hepatocytes and human L02 hepatocytes treated with Palmitic acid (HY-N0830), which correlates with the reduction of Palmitic acid-induced apoptosis and oxidative stress levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse BMCs
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Concentration:0.5 μM
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Incubation Time:2, 6, 12 h
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Result:Enhanced the expression of IL-1β, IL-23a, IL-6, and TNF-α mRNA in LPS-induced mouse blood monocytes.
Chemical Information
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CAS No. 5966-28-9
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Appearance Solid
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Molecular Weight 563.94
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Formula C36H69NO3
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMF : ≥ 100 mg/mL (177.32 mM)
DMSO : ≥ 100 mg/mL (177.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 1.7732 mL | 8.8662 mL | 17.7324 mL | 44.3310 mL |
| 5 mM | 0.3546 mL | 1.7732 mL | 3.5465 mL | 8.8662 mL | |
| 10 mM | 0.1773 mL | 0.8866 mL | 1.7732 mL | 4.4331 mL | |
| 15 mM | 0.1182 mL | 0.5911 mL | 1.1822 mL | 2.9554 mL | |
| 20 mM | 0.0887 mL | 0.4433 mL | 0.8866 mL | 2.2165 mL | |
| 25 mM | 0.0709 mL | 0.3546 mL | 0.7093 mL | 1.7732 mL | |
| 30 mM | 0.0591 mL | 0.2955 mL | 0.5911 mL | 1.4777 mL | |
| 40 mM | 0.0443 mL | 0.2217 mL | 0.4433 mL | 1.1083 mL | |
| 50 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.8866 mL | |
| 60 mM | 0.0296 mL | 0.1478 mL | 0.2955 mL | 0.7388 mL | |
| 80 mM | 0.0222 mL | 0.1108 mL | 0.2217 mL | 0.5541 mL | |
| 100 mM | 0.0177 mL | 0.0887 mL | 0.1773 mL | 0.4433 mL |
C18:1-Ceramide Related Classifications
HY-141578 Related Classifications
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Keywords
- C18:1-Ceramide
- 5966-28-9
- Endogenous Metabolite
- mouse blood mononuclear cells
- murine immune cells
- human L02 hepatocytes
- alkaline ceramidase 3
- colonic epithelial cells
- primary peritoneal macrophages
- Acer3-deficient mouse primary hepatocytes
- DSS-induced colitis
- skeletal muscle insulin resistance
- colon tissues
- Inhibitor
- inhibitor
- inhibit