C6 Ceramide-d₁₁ (Synonyms: C6-Cer-d₁₁; N-Hexanoylsphingosine-d₁₁)

Name: C6 Ceramide-d 11
Brand: MedChemExpress
SKU: HY-19542S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-19542S1: Data Sheet Handling Instructions
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C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.

For research use only. We do not sell to patients.

C6 Ceramide-d₁₁ Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solid
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
2 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
25 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of C6 Ceramide-d₁₁:

C6 Ceramide In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

408.70

Formula

C₂₄H₃₆D₁₁NO₃

Unlabeled CAS

124753-97-5

Appearance

Solid

SMILES

CCCCCCCCCCCCC/C=C/[C@](O)([H])[C@@]([H])(NC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (244.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4468 mL	12.2339 mL	24.4678 mL
5 mM	0.4894 mL	2.4468 mL	4.8936 mL
10 mM	0.2447 mL	1.2234 mL	2.4468 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117. [Content Brief]

[3]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4468 mL	12.2339 mL	24.4678 mL	61.1696 mL
	5 mM	0.4894 mL	2.4468 mL	4.8936 mL	12.2339 mL
	10 mM	0.2447 mL	1.2234 mL	2.4468 mL	6.1170 mL
	15 mM	0.1631 mL	0.8156 mL	1.6312 mL	4.0780 mL
	20 mM	0.1223 mL	0.6117 mL	1.2234 mL	3.0585 mL
	25 mM	0.0979 mL	0.4894 mL	0.9787 mL	2.4468 mL
	30 mM	0.0816 mL	0.4078 mL	0.8156 mL	2.0390 mL
	40 mM	0.0612 mL	0.3058 mL	0.6117 mL	1.5292 mL
	50 mM	0.0489 mL	0.2447 mL	0.4894 mL	1.2234 mL
	60 mM	0.0408 mL	0.2039 mL	0.4078 mL	1.0195 mL
	80 mM	0.0306 mL	0.1529 mL	0.3058 mL	0.7646 mL
	100 mM	0.0245 mL	0.1223 mL	0.2447 mL	0.6117 mL

C6 Ceramide-d₁₁ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C6 Ceramide-d₁₁C6-Cer-d₁₁N-Hexanoylsphingosine-d₁₁ApoptosisIsotope-Labeled Compoundsceramide pathwayadjuvantchemotherapeutic drugsInhibitorinhibitorinhibit

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C6 Ceramide-d11 (Synonyms: C6-Cer-d11; N-Hexanoylsphingosine-d11)

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Other Forms of C6 Ceramide-d11:

C6 Ceramide-d11 Related Antibodies

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

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C6 Ceramide-d11 Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

C6 Ceramide-d11 Related Classifications

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C6 Ceramide-d₁₁ (Synonyms: C6-Cer-d₁₁; N-Hexanoylsphingosine-d₁₁)

Other Forms of C6 Ceramide-d₁₁:

C6 Ceramide-d₁₁ Related Antibodies

C6 Ceramide-d₁₁ Related Antibodies

C6 Ceramide-d₁₁ Related Classifications