C6 Ceramide-d11
Based on 1 Customer Validation
C6 Ceramide-d11 is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.79%
- Fòrmula: C24H36D11NO3
- Peso molecular:408.70
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 124753-97-5
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Appearance Solid
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Peso molecular 408.70
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Fòrmula C24H36D11NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCC/C=C/[C@](O)([H])[C@@]([H])(NC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)CO
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Synonyms
C6-Cer-d11; N-Hexanoylsphingosine-d11
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (244.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117. [Content Brief]
[3]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4468 mL | 12.2339 mL | 24.4678 mL | 61.1696 mL |
| 5 mM | 0.4894 mL | 2.4468 mL | 4.8936 mL | 12.2339 mL | |
| 10 mM | 0.2447 mL | 1.2234 mL | 2.4468 mL | 6.1170 mL | |
| 15 mM | 0.1631 mL | 0.8156 mL | 1.6312 mL | 4.0780 mL | |
| 20 mM | 0.1223 mL | 0.6117 mL | 1.2234 mL | 3.0585 mL | |
| 25 mM | 0.0979 mL | 0.4894 mL | 0.9787 mL | 2.4468 mL | |
| 30 mM | 0.0816 mL | 0.4078 mL | 0.8156 mL | 2.0390 mL | |
| 40 mM | 0.0612 mL | 0.3058 mL | 0.6117 mL | 1.5292 mL | |
| 50 mM | 0.0489 mL | 0.2447 mL | 0.4894 mL | 1.2234 mL | |
| 60 mM | 0.0408 mL | 0.2039 mL | 0.4078 mL | 1.0195 mL | |
| 80 mM | 0.0306 mL | 0.1529 mL | 0.3058 mL | 0.7646 mL | |
| 100 mM | 0.0245 mL | 0.1223 mL | 0.2447 mL | 0.6117 mL |
C6 Ceramide-d11 Related Classifications
HY-19542S1 Related Classifications
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