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Cat. No.: HY-185379

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STING antagonist-3

STING antagonist-3 is a potent STING antagonist with an IC₅₀ of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders.

For research use only. We do not sell to patients.

CAS No.: 3106554-00-8
Formula: C₃₅H₃₉N₅O₃
Molecular Weight:577.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STING antagonist-3 Chemical Structure

CAS No.: 3106554-00-8

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

STING antagonist-3 (Example 21) inhibits human wild-type STING^R232 with an IC₅₀ of 2.3 nM in the competitive HTRF binding assay^[1].
STING antagonist-3 (100 μM; temperature ramp from 15°C to 95°C over 160 cycles) stabilizes human wild-type STING protein against thermal denaturation with a ΔT_m of 29 K in the DSF assay^[1].
STING antagonist-3 (10 μM; 60 min (pre-incubation); 22 h (post-stimulation)) inhibits cGAMP-stimulated IFNα2α production in human whole blood with an IC₅₀ of 0.029 μM^[1].
STING antagonist-3 (1 h (pre-incubation); 6 h (stimulation)) inhibits dsDNA-stimulated IP-10 production in human HMVEC cells with an IC₅₀ of 6.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3106554-00-8
Molecular Weight 577.72
Formula C₃₅H₃₉N₅O₃
SMILES

CC(N=C([C@@H]1CC[C@H](CC1)C(O)=O)C=C2)=C2N3C(C)=C(C(C)C)C(C4=CC=CC5=NN(C[C@H](O)C6=CC=CC=C6)C=C54)=N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matthias Hoffmann, et al. Heterocyclic acids as sting antagonists and the use thereof as medicament, WO, WO2025228902A1, 2025-11-06.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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