1. Immunology/Inflammation
  2. STING
  3. STING agonist-3 trihydrochloride

STING agonist-3 trihydrochloride 

Cat. No.: HY-103665A
Handling Instructions

STING agonist-3 trihydrochloride, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. STING agonist-3 trihydrochloride induces activation of STING and secretion of IFN-β with ECapp50 values of 130 nM, 186 nM in human PBMCs and Mouse PBMCs.

For research use only. We do not sell to patients.

STING agonist-3 trihydrochloride Chemical Structure

STING agonist-3 trihydrochloride Chemical Structure

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Description

STING agonist-3 trihydrochloride, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. STING agonist-3 trihydrochloride induces activation of STING and secretion of IFN-β with ECapp50 values of 130 nM, 186 nM in human PBMCs and Mouse PBMCs[1].

IC50 & Target

STING[1]

In Vitro

STING agonist-3 trihydrochloride induces dose-dependent activation of STING and secretion of IFN-β with ECapp50s of 130 nM, 186 nM in human PBMCs and Mouse PBMCs[1].

In Vivo

STING agonist-3 trihydrochloride (subcutaneous injection; 2.5mg/kg) activates secretion of IFN-β, IL-6, TNF-α, and KC/GROα (CXCL1) in wild-type but not Sting−/− mice, induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1].
STING agonist-3 trihydrochloride (subcutaneous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations with EC50=200 ng /ml for mouse STING[1].
STING agonist-3 trihydrochloride (injection intravenously; 1.5 mg/kg) results in significant tumor growth inhibition, and improves survival with 8 out of 10 mice remaining tumors free at day 43[1].

Molecular Weight

860.19

Formula

C₃₇H₄₅Cl₃N₁₂O₆

SMILES

O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC(C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1.Cl.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

STING agonist-3 trihydrochlorideSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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STING agonist-3 trihydrochloride
Cat. No.:
HY-103665A
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