1. Immunology/Inflammation
  2. STING
  3. MSA-2

MSA-2 

Cat. No.: HY-136927
Handling Instructions

MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.

For research use only. We do not sell to patients.

MSA-2 Chemical Structure

MSA-2 Chemical Structure

CAS No. : 129425-81-6

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Description

MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1].

In Vivo

MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1].
MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor[1].

Animal Model: MC38 tumor-bearing C57BL6 mice[1]
Dosage: 60 mg/kg
Administration: P.o. ; s.c (50 mg/kg); single dose
Result: PO or SC doses of MSA-2 that effectively inhibited tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor.
Molecular Weight

294.32

Formula

C₁₄H₁₄O₅S

CAS No.

129425-81-6

SMILES

O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MSA-2MSA2MSA 2STINGStimulator of Interferon GenesTMEM173MITAERISMPYSinterferon-βsecretionimmunityMC38tumorTNF-αInhibitorinhibitorinhibit

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MSA-2
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HY-136927
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