129425-81-6
Chemical Structure
MSA-2
- CAS No.: 129425-81-6
- Formula:C14H14O5S
- Molecular Weight:294.32
IUPAC Name: 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
InChIKey: APCLRHPWFCQIMG-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O
Biological Activity: MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].
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MSA-2 | 99.81% | MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. | ||||||||||||||||||||
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- [1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098. [Content Brief]
- [2]. Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6(1):18. Published 2021 Jan 12. [Content Brief]
Keywords
