2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP sodium

2',3'-cGAMP sodium  (Synonyms: 2'-3'-cyclic GMP-AMP sodium)

Cat. No.: HY-100564A Purity: 99.72%
COA Handling Instructions

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.

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2',3'-cGAMP sodium Chemical Structure

2',3'-cGAMP sodium Chemical Structure

CAS No. : 2734858-36-5

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1 mg USD 300 In-stock
5 mg USD 690 In-stock
10 mg USD 1250 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP sodium:

2',3'-cGAMP sodium Related Antibodies

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Description

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50 & Target

STING, IFNβ[1]
In Vitro

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2',3'-cGAMP sodium Related Antibodies
Molecular Weight

718.37

Appearance

Solid

Formula

C20H22N10Na2O13P2
CAS No.
SMILES

OC1([H])[C@](OP(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)(O[Na])=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (69.60 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3920 mL 6.9602 mL 13.9204 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL
10 mM 0.1392 mL 0.6960 mL 1.3920 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 18.33 mg/mL (25.52 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

COA (251 KB) HNMR (249 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References
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2',3'-cGAMP sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2',3'-cGAMP2734858-36-52'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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