1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Endogenous Metabolite
    STING
    IFNAR
  3. 2',3'-cGAMP

2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP)

Cat. No.: HY-100564
Handling Instructions

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

For research use only. We do not sell to patients.

2',3'-cGAMP Chemical Structure

2',3'-cGAMP Chemical Structure

CAS No. : 1441190-66-4

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Description

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

674.41

Formula

C₂₀H₂₄N₁₀O₁₃P₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (7.41 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4828 mL 7.4139 mL 14.8278 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
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2',3'-cGAMP
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HY-100564
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