1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Endogenous Metabolite
    STING
  3. 2',3'-cGAMP

2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP)

Cat. No.: HY-100564
Handling Instructions

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a molecule in endogenous cGAMP mammalian cells which contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP. 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm and binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ).

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2',3'-cGAMP Chemical Structure

2',3'-cGAMP Chemical Structure

CAS No. : 1441190-66-4

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Description

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a molecule in endogenous cGAMP mammalian cells which contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP. 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm and binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ)[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

Molecular Weight

674.41

Formula

C₂₀H₂₄N₁₀O₁₃P₂

CAS No.

1441190-66-4

SMILES

OC1([H])[[email protected]](OP(O)(OC[[email protected]](O[[email protected]@H](N2C3=NC=NC(N)=C3N=C2)[[email protected]@H]4O)([H])[[email protected]@]4([H])O5)=O)([H])[[email protected]](N6C(NC(N)=NC7=O)=C7N=C6)O[[email protected]]1([H])COP5(O)=O

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2',3'-cGAMP
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