1. Metabolic Enzyme/Protease Immunology/Inflammation
  2. Endogenous Metabolite STING IFNAR
  3. 2',3'-cGAMP

2',3'-cGAMP  (Synonyms: 2'-3'-cyclic GMP-AMP)

Cat. No.: HY-100564 Purity: 99.71%
COA Handling Instructions

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

For research use only. We do not sell to patients.

2',3'-cGAMP Chemical Structure

2',3'-cGAMP Chemical Structure

CAS No. : 1441190-66-4

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1 mg USD 300 In-stock
5 mg USD 690 In-stock
10 mg USD 1250 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP:

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Description

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50 & Target

STING, IFNβ[1]

In Vitro

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

674.41

Formula

C20H24N10O13P2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (74.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4828 mL 7.4139 mL 14.8278 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL
10 mM 0.1483 mL 0.7414 mL 1.4828 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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2',3'-cGAMP
Cat. No.:
HY-100564
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