2',3'-cGAMP
Based on 34 publication(s) in Google Scholar
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 1441190-66-4
- Formula: C20H24N10O13P2
- Molecular Weight:674.41
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2',3'-cGAMP
More- Adv Mater. 2024 Mar 24:e2401384. [Abstract]
- Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
- ACS Nano. 2026 Mar 17;20(10):8236-8254. [Abstract]
- ACS Nano. 2025 Feb 25;19(7):6758-6770. [Abstract]
- Nat Commun. 2025 Jun 3;16(1):5140. [Abstract]
- Neuron. 2023 Jan 18;111(2):236-255.e7. [Abstract]
- Adv Sci (Weinh). 2024 Dec 11:e2408323. [Abstract]
- Adv Sci (Weinh). 2024 Nov 19:e2407222. [Abstract]
- Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
- Genes Dis. 2025 Aug 14.
- Cell Commun Signal. 2023 Sep 28;21(1):264. [Abstract]
- Brain Behav Immun. 2026 Jan:131:106176. [Abstract]
- Cell Rep. 2023 Feb 28;42(3):112145. [Abstract]
- J Med Chem. 2026 May 14;69(9):11044-11071. [Abstract]
- J Med Chem. 2025 Mar 13;68(5):5471-5487. [Abstract]
- Oncoimmunology. 2025 Dec 31;14(1):2590245. [Abstract]
- Fundam Res. 2023 May 11;5(1):183-191. [Abstract]
- ACS Appl Bio Mater. 2024 Oct 21;7(10):6768-6779. [Abstract]
- Neuropharmacology. 2025 Mar 19:110426. [Abstract]
- Cancers (Basel). 2024 Oct 30;16(21):3657. [Abstract]
- J Biol Chem. 2025 Dec 6;302(1):111021. [Abstract]
- J Virol. 2023 Nov 30;97(11):e0127923. [Abstract]
- Hum Vaccin Immunother. 2025 Dec;21(1):2567703. [Abstract]
- J Immunol. 2021 Apr 15;206(8):1844-1857. [Abstract]
- World J Tradit Chin Med. 2025 Oct 28.
- Transbound Emerg Dis. 2025 Dec 11:2025:9584967. [Abstract]
- Clin Rheumatol. 2026 Mar;45(3):1709-1720. [Abstract]
- Mol Pain. 2025 May 7:17448069251342240. [Abstract]
- Res Sq. 2026 Jan 22.
- bioRxiv. 2025 Nov 17:2025.11.17.687821. [Abstract]
- SSRN. 2025 Jan 24.
- Res Sq. 2024 May 30.
- bioRxiv. 2024 Apr 12.
- Acta Materia Medica . 2023 Jun 17.
Customer Validation & Images
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WB
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ELISA
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Flow Cytometry
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In Vivo Efficacy Study
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Flow Cytometry
All Endogenous Metabolite Isoforms
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Biological Activity
STING, IFNβ[1]
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1441190-66-4
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Appearance Solid
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Molecular Weight 674.41
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Formula C20H24N10O13P2
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Color White to off-white
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SMILES
OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
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Synonyms
2'-3'-cyclic GMP-AMP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (34)
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Journal Impact Factor
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Most Recent
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Adv Mater
A T-cell Inspired Sonoporation System Enhances Low-dose X-ray-mediated Pyroptosis and Radioimmunotherapy Efficacy by Restoring Gasdermin-E Expression. [Abstract]2024 Mar 24:e2401384. PMID: 38521987 -
Bioact Mater
STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy. [Abstract]2024 Sep 6:42:345-365. PMID: 39290338
2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
Western blot assay of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM inducing TBK1, STING, NF-κB and IRF3 phosphorylation in BMDCs in vitro.
2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
ELISA assay of IFN-β produced by 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs in vitro.
2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
Flow cytometric analysis of surface biomarkers for DC maturation, antigen cross-presentation, and LN homing ability of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs.
2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
Graph presenting tumor volume growth of the B16-OVA tumor-bearing C57BL-6 mice following different treatments over a 16-day period (n = 5). 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days.
2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]
B16-OVA tumor-bearing C57BL-6 mice were given different treatments over a 16-day period (n = 5), 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days. Illustrative flow cytometric graphs and proportions of T cells in tumor tissues observed on day 7 after the last vaccination.
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ACS Nano
Reprogramming Postablation Tumor Immune Microenvironment with Dual-Function Nanotherapeutic Immunomodulator for Synergistic Antitumor Immunity and Recurrence Suppression. [Abstract]2026 Mar 17;20(10):8236-8254. PMID: 41778965 -
ACS Nano
A pH-Responsive and Guanidinium-Rich Nanoadjuvant Efficiently Delivers STING Agonist for Cancer Immunotherapy. [Abstract]2025 Feb 25;19(7):6758-6770. PMID: 39933120 -
Nat Commun
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS. [Abstract]2025 Jun 3;16(1):5140. PMID: 40461475 -
Neuron
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis. [Abstract]2023 Jan 18;111(2):236-255.e7. PMID: 36370710 -
Adv Sci (Weinh)
Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma. [Abstract]2024 Dec 11:e2408323. PMID: 39661716 -
Adv Sci (Weinh)
2024 Nov 19:e2407222. PMID: 39558862 -
Protein Cell
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. [Abstract]2022 Apr;13(4):281-301. PMID: 34677780 -
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Cell Commun Signal
RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway. [Abstract]2023 Sep 28;21(1):264. PMID: 37770901 -
Brain Behav Immun
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication. [Abstract]2026 Jan:131:106176. PMID: 41238086 -
Cell Rep
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING. [Abstract]2023 Feb 28;42(3):112145. PMID: 36862550 -
J Med Chem
Discovery of a New Tetrahydroquinoline-Based Chemotype for STING Inhibition with In Vivo Efficacy against Acute Kidney Injury. [Abstract]2026 May 14;69(9):11044-11071. PMID: 41999331 -
J Med Chem
Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid. [Abstract]2025 Mar 13;68(5):5471-5487. PMID: 40014799 -
Oncoimmunology
Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer. [Abstract]2025 Dec 31;14(1):2590245. PMID: 41351298 -
Fundam Res
Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses. [Abstract]2023 May 11;5(1):183-191. PMID: 40166097 -
ACS Appl Bio Mater
A Multifunctional Nanoparticle Dual Loading with Chlorin e6 and STING Agonist for Combinatorial Therapy of Melanoma. [Abstract]2024 Oct 21;7(10):6768-6779. PMID: 39289781 -
Neuropharmacology
Artesunate demonstrates neuroprotective effect through activation of lysosomal function and inhibition of cGAS-STING pathway. [Abstract]2025 Mar 19:110426. PMID: 40118208 -
Cancers (Basel)
Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Liposomes Loaded with STING Agonist Enhances Immune Activation for Breast Cancer Immunotherapy. [Abstract]2024 Oct 30;16(21):3657. PMID: 39518096 -
J Biol Chem
Dynamic control of bacterial antiphage defense through the CdnG-Cap5 cyclic oligonucleotide-based antiphage pathway in Vibrio cholerae. [Abstract]2025 Dec 6;302(1):111021. PMID: 41360261 -
J Virol
Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants. [Abstract]2023 Nov 30;97(11):e0127923. PMID: 37843372 -
Hum Vaccin Immunother
2025 Dec;21(1):2567703. PMID: 41055008 -
J Immunol
African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS-STING-Mediated Signaling Pathway. [Abstract]2021 Apr 15;206(8):1844-1857. PMID: 33712518 -
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Transbound Emerg Dis
RACK1 Associates With STING to Promote Type I Interferon Activation and Inhibit Pseudorabies Virus Infection. [Abstract]2025 Dec 11:2025:9584967. PMID: 41395239 -
Clin Rheumatol
PP2A dysfunction mediated by PPP2R1A deficiency drives cGAS-STING-dependent hyperinflammation in SLE CD14+ monocytes. [Abstract]2026 Mar;45(3):1709-1720. PMID: 41582267 -
Mol Pain
Electroacupuncture intervention relieves pain by stimulating the STING/IFN-I pathway in rat models of cancer-induced bone pain. [Abstract]2025 May 7:17448069251342240. PMID: 40331681 -
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bioRxiv
2025 Nov 17:2025.11.17.687821. PMID: 41332698 -
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Solvent & Solubility
H2O : ≥ 50 mg/mL (74.14 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4828 mL | 7.4139 mL | 14.8278 mL | 37.0694 mL |
| 5 mM | 0.2966 mL | 1.4828 mL | 2.9656 mL | 7.4139 mL | |
| 10 mM | 0.1483 mL | 0.7414 mL | 1.4828 mL | 3.7069 mL | |
| 15 mM | 0.0989 mL | 0.4943 mL | 0.9885 mL | 2.4713 mL | |
| 20 mM | 0.0741 mL | 0.3707 mL | 0.7414 mL | 1.8535 mL | |
| 25 mM | 0.0593 mL | 0.2966 mL | 0.5931 mL | 1.4828 mL | |
| 30 mM | 0.0494 mL | 0.2471 mL | 0.4943 mL | 1.2356 mL | |
| 40 mM | 0.0371 mL | 0.1853 mL | 0.3707 mL | 0.9267 mL | |
| 50 mM | 0.0297 mL | 0.1483 mL | 0.2966 mL | 0.7414 mL | |
| 60 mM | 0.0247 mL | 0.1236 mL | 0.2471 mL | 0.6178 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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