1. Immunology/Inflammation
  2. STING
  3. SR-717

SR-717 

Cat. No.: HY-131454 Purity: 99.75%
Handling Instructions

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity.

For research use only. We do not sell to patients.

SR-717 Chemical Structure

SR-717 Chemical Structure

CAS No. : 2375421-09-1

Size Price Stock Quantity
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity[1].

In Vitro

SR-717 is a stable cGAMP mimetic that activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity[1].
SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner[1].

In Vivo

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

Animal Model: WT or Stinggt/gt mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneally; once-per-day for 1 week
Result: Maximally inhibited tumor growth.
Molecular Weight

351.19

Formula

C₁₅H₈F₂LiN₅O₃

CAS No.

2375421-09-1

SMILES

O=C(O[Li])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (40.69 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8475 mL 14.2373 mL 28.4746 mL
5 mM 0.5695 mL 2.8475 mL 5.6949 mL
10 mM 0.2847 mL 1.4237 mL 2.8475 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.43 mg/mL (4.07 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.43 mg/mL (4.07 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (4.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SR-717SR717SR 717STINGStimulator of Interferon GenesTMEM173MITAERISMPYSISG-THP1cGAMPmimeticantitumorimmunityPD-L1THP1Inhibitorinhibitorinhibit

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Product Name:
SR-717
Cat. No.:
HY-131454
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