SR-717 free acid
Based on 31 publication(s) in Google Scholar
SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 2375420-34-9
- Formula: C15H9F2N5O3
- Molecular Weight:345.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SR-717 free acid
More- Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]
- Nat Commun. 2025 Dec 12;16(1):11314. [Abstract]
- Nat Commun. 2023 Aug 22;14(1):5111. [Abstract]
- Cell Death Differ. 2024 Jan;31(1):78-89. [Abstract]
- Adv Sci (Weinh). 2024 Nov 19:e2407222. [Abstract]
- Chem Eng J. 2025 May 1.
- J Control Release. 2026 Feb 15:392:114733. [Abstract]
- Sci China Life Sci. 2024 Dec;67(12):2664-2677. [Abstract]
- Cancer Biol Med. 2026 Feb 16;23(1):133-153. [Abstract]
- Acta Pharmacol Sin. 2025 Oct 17. [Abstract]
- Phytomedicine. 2025 Nov 26:150:157625. [Abstract]
- ACS Appl Mater Interfaces. 2026 Feb 18;18(6):9379-9400. [Abstract]
- Free Radic Biol Med. 2025 Oct 25.
- Sci Total Environ. 2023 Dec 20:905:167315. [Abstract]
- Clin Sci. 2023 Mar 31;137(6):435-452. [Abstract]
- Antioxid Redox Signal. 2025 Sep 29. [Abstract]
- Biochem Pharmacol. 2025 Sep 14;242(Pt 2):117334. [Abstract]
- Biochem Pharmacol. 2023 Jul:213:115618. [Abstract]
- Am J Chin Med. 2024;52(2):471-492. [Abstract]
- Int J Pharm. 2023 Nov 5:646:123430. [Abstract]
- Int Immunopharmacol. 2024 Oct 17;143(Pt 2):113401. [Abstract]
- Eur J Pharmacol. 2022 Oct 15:932:175241. [Abstract]
- Cell Rep Methods. 2025 Jul 21;5(7):101106. [Abstract]
- FASEB J. 2026 Mar 31;40(6):e71596. [Abstract]
- iScience. 2026 Apr 10;29(5):115711. [Abstract]
- Fish Shellfish Immunol. 2025 Aug 6:166:110640. [Abstract]
- Biomedicines. 2023 Sep 20;11(9):2579. [Abstract]
- Cell Signal. 2026 Mar 6.
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- Cell Insight. 2025 May 22;4(4):100255. [Abstract]
- Research Square Print. 2023 Feb 2.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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IF
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RT-PCR
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Flow Cytometry
Biological Activity
SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity[1].
SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT or Stinggt/gt mice[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneally; once-per-day for 1 week
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Result:Maximally inhibited tumor growth.
Chemical Information
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CAS No. 2375420-34-9
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Appearance Solid
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Molecular Weight 345.26
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Formula C15H9F2N5O3
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Color Off-white to light yellow
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SMILES
O=C(O)C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (31)
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Journal Impact Factor
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Most Recent
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Immunity
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement. [Abstract]2025 Dec 5:S1074-7613(25)00506-0. PMID: 41352342 -
Nat Commun
Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]2025 Dec 12;16(1):11314. PMID: 41387431
SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314. [Abstract]
CCK8 assays revealed that SR717 significantly reversed the increase in cell viability induced by TF/PS/TDP-43-IN-1 in primary astrocytes and microglia.
SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314. [Abstract]
Western blot analysis showed SR717 reduced expression of C3 and S100A10 in astrocytes and decreased CD86 and CD206 levels in microglia after treatment, indicating reversal of inflammatory phenotypes.
SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314. [Abstract]
Immunofluorescence SR717 reversed the C3 and S100A10 expression changes in injured primary astrocytes and CD86 and CD206 expression in microglia induced by TF/PS/TDP-43-IN-1.
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Nat Commun
Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy. [Abstract]2023 Aug 22;14(1):5111. PMID: 37607938
SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Aug 22;14(1):5111. [Abstract]
SR-717 (10 mg/kg, i.v.) increased PD-L1 expression on tumor cells by flow cytometry.
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Cell Death Differ
Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer. [Abstract]2024 Jan;31(1):78-89. PMID: 38007552 -
Adv Sci (Weinh)
2024 Nov 19:e2407222. PMID: 39558862 -
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J Control Release
Protein corona-guided delivery of dextran-PLGA NPs for enhanced dendritic cell uptake, maturation and improved cancer immunotherapy. [Abstract]2026 Feb 15:392:114733. PMID: 41702510 -
Sci China Life Sci
Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases. [Abstract]2024 Dec;67(12):2664-2677. PMID: 39190126 -
Cancer Biol Med
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [Abstract]2026 Feb 16;23(1):133-153. PMID: 41700809 -
Acta Pharmacol Sin
Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects. [Abstract]2025 Oct 17. PMID: 41107405 -
Phytomedicine
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis. [Abstract]2025 Nov 26:150:157625. PMID: 41338109 -
ACS Appl Mater Interfaces
Ultrasound-Responsive Cerasome Nanoparticle Improves STING-Driven Immunotherapy in Triple-Negative Breast Cancer. [Abstract]2026 Feb 18;18(6):9379-9400. PMID: 41660697 -
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Sci Total Environ
Mitochondrial DNA release mediated by TFAM deficiency promotes copper-induced mitochondrial innate immune response via cGAS-STING signalling in chicken hepatocytes. [Abstract]2023 Dec 20:905:167315. PMID: 37742962 -
Clin Sci
Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling. [Abstract]2023 Mar 31;137(6):435-452. PMID: 36815438 -
Antioxid Redox Signal
Endothelial Gasdermin D Induces Mitochondrial Damage and Activates the STING Pathway in Lipopolysaccharide-Accelerated Atherosclerosis. [Abstract]2025 Sep 29. PMID: 41017337
SR-717 free acid purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Sep 29. [Abstract]
SR-717 (10 mg/kg, i.p.) increased the mRNA expression levels of IL-1β, IL-6, IL-18, and MCP-1 mRNA levels as determined by qPCR.
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Biochem Pharmacol
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke. [Abstract]2025 Sep 14;242(Pt 2):117334. PMID: 40957492 -
Biochem Pharmacol
2023 Jul:213:115618. PMID: 37211172 -
Am J Chin Med
Apigenin Suppresses Innate Immune Responses and Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of STING/IRF3 Pathway. [Abstract]2024;52(2):471-492. PMID: 38480499 -
Int J Pharm
Enhancement of cancer immunotherapy using CRT valgus tumor cell membranes coated bacterial whole peptidoglycan combined with radiotherapy. [Abstract]2023 Nov 5:646:123430. PMID: 37742823 -
Int Immunopharmacol
Corilagin inhibits human cytomegalovirus infection and replication via activating the cGAS-STING signaling pathway in vitro and in vivo. [Abstract]2024 Oct 17;143(Pt 2):113401. PMID: 39423664 -
Eur J Pharmacol
Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis. [Abstract]2022 Oct 15:932:175241. PMID: 36058291 -
Cell Rep Methods
A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy. [Abstract]2025 Jul 21;5(7):101106. PMID: 40669456 -
FASEB J
2026 Mar 31;40(6):e71596. PMID: 41830493 -
iScience
2026 Apr 10;29(5):115711. PMID: 42095073 -
Fish Shellfish Immunol
2025 Aug 6:166:110640. PMID: 40780681 -
Biomedicines
GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation. [Abstract]2023 Sep 20;11(9):2579. PMID: 37761020 -
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J Integr Neurosci
Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice. [Abstract]2025 Aug 22;24(8):39286. PMID: 40919625 -
Cell Insight
2025 May 22;4(4):100255. PMID: 40586041 -
Solvent & Solubility
H2O : 6.11 mg/mL (17.70 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.8964 mL | 14.4818 mL | 28.9637 mL | 72.4092 mL |
| 5 mM | 0.5793 mL | 2.8964 mL | 5.7927 mL | 14.4818 mL | |
| 10 mM | 0.2896 mL | 1.4482 mL | 2.8964 mL | 7.2409 mL | |
| 15 mM | 0.1931 mL | 0.9655 mL | 1.9309 mL | 4.8273 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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