2. Immunology/Inflammation
  3. STING
  4. SR-717 free acid

SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 2375420-34-9

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Based on 30 publication(s) in Google Scholar

Other Forms of SR-717 free acid:

SR-717 free acid Related Antibodies

Top Publications Citing Use of Products

30 Publications Citing Use of MCE SR-717 free acid

Cell Proliferation/Viability Assay
Flow Cytometry
RT-PCR
WB
IF

    SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314.  [Abstract]

    CCK8 assays revealed that SR717 significantly reversed the increase in cell viability induced by TF/PS/TDP-43-IN-1 in primary astrocytes and microglia.

    SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314.  [Abstract]

    Western blot analysis showed SR717 reduced expression of C3 and S100A10 in astrocytes and decreased CD86 and CD206 levels in microglia after treatment, indicating reversal of inflammatory phenotypes.

    SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11314.  [Abstract]

    Immunofluorescence SR717 reversed the C3 and S100A10 expression changes in injured primary astrocytes and CD86 and CD206 expression in microglia induced by TF/PS/TDP-43-IN-1.

    SR-717 free acid purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Sep 29.  [Abstract]

    SR-717 (10 mg/kg, i.p.) increased the mRNA expression levels of IL-1β, IL-6, IL-18, and MCP-1 mRNA levels as determined by qPCR.

    SR-717 free acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Aug 22;14(1):5111.  [Abstract]

    SR-717 (10 mg/kg, i.v.) increased PD-L1 expression on tumor cells by flow cytometry.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].

    In Vitro

    SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity[1].
    SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SR-717 free acid Related Antibodies
    In Vivo

    SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
    SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: WT or Stinggt/gt mice[1]
    Dosage: 30 mg/kg
    Administration: Intraperitoneally; once-per-day for 1 week
    Result: Maximally inhibited tumor growth.
    Molecular Weight

    345.26

    Formula

    C15H9F2N5O3
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(O)C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 6.11 mg/mL (17.70 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8964 mL 14.4818 mL 28.9637 mL
    5 mM 0.5793 mL 2.8964 mL 5.7927 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.8964 mL 14.4818 mL 28.9637 mL 72.4092 mL
    5 mM 0.5793 mL 2.8964 mL 5.7927 mL 14.4818 mL
    10 mM 0.2896 mL 1.4482 mL 2.8964 mL 7.2409 mL
    15 mM 0.1931 mL 0.9655 mL 1.9309 mL 4.8273 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    SR-717 free acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SR-7172375420-34-9SR717SR 717STINGStimulator of Interferon GenesTMEM173MITAERISMPYSISG-THP1cGAMPmimeticantitumorimmunityPD-L1THP1Inhibitorinhibitorinhibit

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