1. Immunology/Inflammation
  2. STING
  3. diABZI STING agonist-1 trihydrochloride

diABZI STING agonist-1 trihydrochloride 

Cat. No.: HY-112921B Purity: 99.89%
Handling Instructions

diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.

For research use only. We do not sell to patients.

diABZI STING agonist-1 trihydrochloride Chemical Structure

diABZI STING agonist-1 trihydrochloride Chemical Structure

CAS No. : 2138299-34-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 791 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Other Forms of diABZI STING agonist-1 trihydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.

IC50 & Target

STING[1].

In Vivo

diABZI STING agonist-1 (trihydrochloride) activates secretion of IFNβ, IL-6, TNF, and KC/GROα (also known as CXCL1) in wild-type but not Sting−/− mice, confirming that diABZI STING agonist-1 (trihydrochloride) STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (130.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0424 mL 5.2120 mL 10.4241 mL
5 mM 0.2085 mL 1.0424 mL 2.0848 mL
10 mM 0.1042 mL 0.5212 mL 1.0424 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

959.32

Formula

C₄₂H₅₄Cl₃N₁₃O₇

CAS No.

2138299-34-8

SMILES

O=C(N)C1=CC(N=C(NC(C2=CC(C)=NN2CC)=O)N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)=C3C(OC)=C1.Cl.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.89%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
diABZI STING agonist-1 trihydrochloride
Cat. No.:
HY-112921B
Quantity:

diABZI STING agonist-1 trihydrochloride

Cat. No.: HY-112921B