2. Immunology/Inflammation
  3. STING
  4. diABZI STING agonist-1 (Tautomerism)

diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

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diABZI STING agonist-1 (Tautomerism) Chemical Structure

diABZI STING agonist-1 (Tautomerism) Chemical Structure

CAS No. : 2138498-18-5

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Other Forms of diABZI STING agonist-1 (Tautomerism):

diABZI STING agonist-1 (Tautomerism) Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE diABZI STING agonist-1 (Tautomerism)

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WB

    diABZI STING agonist-1 (Tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of the WCL of the indicated stable 4T1 cells at the indicated time points after treatment with 10 µM STING agonist-1 (diABZI).

    diABZI STING agonist-1 (Tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of EVPs isolated from HeLa, HCT116, and B16F10 cells treated with or without 10 µM STING agonist-1 (diABZI), 1 µM cGAMP, or 50 µg/mL DMXAA for 48 h.

    diABZI STING agonist-1 (Tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Immunofluorescence analysis of STING (green) and Flag-RAB22AQ64L (red) in stable Flag-RAB22AQ64L NCI-H1975 cells treated with or without 1 µM STING agonist-1 (diABZI) for 1 h.

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    Description

    diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

    IC50 & Target

    EC50: 130 nM (human STNG in PBMCs) [1].
    In Vitro

    diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    diABZI STING agonist-1 (Tautomerism) Related Antibodies
    In Vivo

    diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1].
    diABZI STING agonist-1 (Tautomerism) (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/ml)[1].
    diABZI STING agonist-1 (Tautomerism) (intravenous injection; 1.5 mg/kg; 43 days) results in significant tumour growth inhibition and significantly improves survival (P < 0.001) with 8 out of 10 mice remaining tumor free at the end of the study on day 43[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Wild and Sting−/− C57Blk6 mice
    Dosage: 2.5 mg/kg
    Administration: Subcutaneous injection; 2.5 mg/kg
    Result: Activated secretion of IFNβ, IL-6, TNF, and CXCL1 in wild-type but not Sting−/− mice.
    Animal Model: Syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice[1]
    Dosage: 3 mg/kg
    Administration: Intravenous injection; 3 mg/kg
    Result: Exhibited a half-life of 1.4 hours and achieved systemic concentrations greater than EC50 for mouse STING (200 ng/ml).
    Animal Model: Syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice[1]
    Dosage: 1.5 mg/kg
    Administration: Intravenous injection; 1.5 mg/kg; 43 days
    Result: Resulted in significant tumour growth inhibition and improved survival.
    Molecular Weight

    849.94

    Formula

    C42H51N13O7
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(N)C1=CC(N/C(N2C/C=C/CN3/C(NC4=C3C(OCCCN5CCOCC5)=CC(C(N)=O)=C4)=N/C(C6=CC(C)=NN6CC)=O)=N\C(C7=CC(C)=NN7CC)=O)=C2C(OC)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    diABZI STING agonist-1 (Tautomerism) Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    diABZI STING agonist-1 (Tautomerism)2138498-18-5STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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