1. Immunology/Inflammation
  2. STING
  3. STING agonist-4

STING agonist-4 

Cat. No.: HY-123943 Purity: 98.08%
Handling Instructions

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function.

For research use only. We do not sell to patients.

STING agonist-4 Chemical Structure

STING agonist-4 Chemical Structure

CAS No. : 2138300-40-8

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5 mg USD 420 In-stock
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10 mg USD 600 In-stock
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50 mg USD 1800 In-stock
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100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function[1].

IC50 & Target

IC50: 20 nM (STING agonist-4)[1]

In Vitro

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM[1].
STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (Kd) of approximately 1.6 nM[1].
STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC50 of 53.9 μM[1].
STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human peripheral blood mononuclear cells (PBMCs)
Concentration: 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time: 2 hours
Result: Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.
Molecular Weight

678.74

Formula

C34H38N12O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (14.73 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

*STING agonist-4 is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4733 mL 7.3666 mL 14.7332 mL
5 mM 0.2947 mL 1.4733 mL 2.9466 mL
10 mM 0.1473 mL 0.7367 mL 1.4733 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1 mg/mL (1.47 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1 mg/mL (1.47 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References

Purity: 99.52%

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Product Name:
STING agonist-4
Cat. No.:
HY-123943
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