1. Immunology/Inflammation
  2. STING
  3. STING agonist-4

STING agonist-4 

Cat. No.: HY-123943 Purity: >98.0%
Handling Instructions

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function.

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STING agonist-4 Chemical Structure

STING agonist-4 Chemical Structure

CAS No. : 2138300-40-8

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Based on 1 publication(s) in Google Scholar

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Description

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function[1].

IC50 & Target

IC50: 20 nM (STING agonist-4)[1]

In Vitro

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM[1].
STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (Kd) of approximately 1.6 nM[1].
STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC50 of 53.9 μM[1].
STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1[1].

Cell Viability Assay[1]

Cell Line: Human peripheral blood mononuclear cells (PBMCs)
Concentration: 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time: 2 hours
Result: Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.
Molecular Weight

678.74

Formula

C₃₄H₃₈N₁₂O₄

CAS No.

2138300-40-8

SMILES

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC(C)=NN6CC)=O)=NC2=C1)N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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STING agonist-4
Cat. No.:
HY-123943
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