1. Metabolic Enzyme/Protease Autophagy
  2. Phospholipase Autophagy
  3. FIPI

FIPI  (Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide)

Cat. No.: HY-12807 Purity: 99.82%
COA Handling Instructions

FIPI (5-Fluoro-2-indolyl des-chlorohalopemide), a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI has the potential for autoimmunity and cancer metastasis research.

For research use only. We do not sell to patients.

FIPI Chemical Structure

FIPI Chemical Structure

CAS No. : 939055-18-2

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Solid + Solvent
10 mM * 1 mL in DMSO
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USD 94 In-stock
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Solid
5 mg USD 85 In-stock
10 mg USD 110 In-stock
50 mg USD 385 In-stock
100 mg USD 600 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of FIPI:

Top Publications Citing Use of Products

    FIPI purchased from MedChemExpress. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748.  [Abstract]

    Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.

    FIPI purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217.  [Abstract]

    ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

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    • Purity & Documentation

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    • Customer Review

    Description

    FIPI (5-Fluoro-2-indolyl des-chlorohalopemide), a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI has the potential for autoimmunity and cancer metastasis research[1][2][3].

    IC50 & Target

    IC50: 25 nM (PLD1), 20 nM (PLD2)

    Molecular Weight

    421.47

    Formula

    C23H24FN5O2

    CAS No.
    Appearance

    Solid

    Color

    Light yellow to khaki

    SMILES

    O=C(C(N1)=CC2=C1C=CC(F)=C2)NCCN3CCC(N4C5=CC=CC=C5NC4=O)CC3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 14.67 mg/mL (34.81 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3726 mL 11.8632 mL 23.7265 mL
    5 mM 0.4745 mL 2.3726 mL 4.7453 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.82%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3726 mL 11.8632 mL 23.7265 mL 59.3162 mL
    5 mM 0.4745 mL 2.3726 mL 4.7453 mL 11.8632 mL
    10 mM 0.2373 mL 1.1863 mL 2.3726 mL 5.9316 mL
    15 mM 0.1582 mL 0.7909 mL 1.5818 mL 3.9544 mL
    20 mM 0.1186 mL 0.5932 mL 1.1863 mL 2.9658 mL
    25 mM 0.0949 mL 0.4745 mL 0.9491 mL 2.3726 mL
    30 mM 0.0791 mL 0.3954 mL 0.7909 mL 1.9772 mL
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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