FIPI hydrochloride
Based on 5 publication(s) in Google Scholar
FIPI hydrochloride is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI hydrochloride regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI hydrochloride can be used in cancer research. In addition, FIPI hydrochloride can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function.
For research use only. We do not sell to patients.
- CAS No.: 1781834-93-2
- Formula: C23H25ClFN5O2
- Molecular Weight:457.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) FIPI hydrochloride
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
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IF
All Phospholipase Isoforms
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Biological Activity
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PLD1 |
PLD2 |
Chemical Information
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CAS No. 1781834-93-2
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Molecular Weight 457.93
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Formula C23H25ClFN5O2
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SMILES
O=C(NCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O)C4=CC5=C(C=CC(F)=C5)N4.[H]Cl
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Synonyms
5-Fluoro-2-indolyl deschlorohalopemide hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Anal Chem
Phospholipid-Tailored Titanium Carbide Nanosheets as a Novel Fluorescent Nanoprobe for Activity Assay and Imaging of Phospholipase D. [Abstract]2018 Jun 5;90(11):6742-6748. PMID: 29737155
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748. [Abstract]
Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.
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Biochem Pharmacol
Phospholipase D2 regulation by transcription factor FOXA1 promotes the drug resistance of vemurafenib in melanoma cells. [Abstract]2025 Dec;242(Pt 4):117434. PMID: 41110487 -
Nanoscale Res Lett
Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis. [Abstract]2019 Apr 18;14(1):138. PMID: 31001703
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]
Cell viability of MDA-MB-231 cells incubated with Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h or 24 h at a concentration of 2 μM FIPI, respectively.
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]
Inhibition effects on the cell motility in vitro. Images of MDA-MB-231 cells wound edge after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 48 h, respectively (magnification, × 100).
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]
Inhibition effects on cell migration. Images of MDA-MB-231 cell migration after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h at a concentration of 2 μM FIPI.
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]
Inhibition effects on the cell invasion. Images of MDA-MB-231 cell invasion after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 24 h a concentration of 2 μM FIPI (magnification, × 100).
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J Cell Sci
The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response. [Abstract]2018 Mar 16;131(6). pii: jcs207217. PMID: 29420297
FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217. [Abstract]
ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.
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Purity & Documentation
References
[1]. Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46. [Content Brief]
[2]. Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1. [Content Brief]
[3]. Claudia Dall'Armi, et al. The phospholipase D1 pathway modulates macroautophagy. Nat Commun. 2010:1:142. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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