1781834-93-2
Chemical Structure
FIPI hydrochloride
Synonym(s): 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride
- CAS No.: 1781834-93-2
- Formula:C23H25ClFN5O2
- Molecular Weight:457.93
IUPAC Name: 5-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide hydrochloride
InChIKey: BNMQCDOCYPGJJD-UHFFFAOYSA-N
SMILES: O=C(NCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O)C4=CC5=C(C=CC(F)=C5)N4.[H]Cl
Biological Activity: FIPI hydrochloride is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI hydrochloride regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI hydrochloride can be used in cancer research. In addition, FIPI hydrochloride can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function[1][2][3].
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FIPI hydrochloride | FIPI hydrochloride is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI hydrochloride regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI hydrochloride can be used in cancer research. In addition, FIPI hydrochloride can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function. | |||||||||||||||||||||
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- [1]. Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46. [Content Brief]
- [2]. Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1. [Content Brief]
- [3]. Claudia Dall'Armi, et al. The phospholipase D1 pathway modulates macroautophagy. Nat Commun. 2010:1:142. [Content Brief]
Keywords